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Muscular Disorders Corrected with Stem Cells

Posted by anna@stemsave.com on Jun 13, 2017 1:00:00 PM

Researchers at Cincinnati Children’s Hospital Medical Center Heart Institute have discovered a possible method of directing stem cells to fuse together and form functional skeletal muscle. Utilizing gene therapy, their research has provided insight into correcting disorders like muscular dystrophy, and congenital and metabolic myopathy. By identifying the genes Gm 7325 and Tmem8c, as well as their corresponding proteins, researchers have determined their paired role in directing muscle stem cells (myoblasts) in fusing and creating functional striated muscle tissue, which is responsible for movement.

 

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Topics: Muscular Dystrophy, myopathy, myoblasts, adult stem cells

Treating ALS With Stem Cells

Posted by anna@stemsave.com on May 10, 2017 1:00:00 PM

Researchers at the Mayo Clinic are researching stem cell treatments for amyotrophic lateral sclerosis (ALS), the onset of which remains unknown and the cure for which has yet to be discovered. For patients with ALS, motor neurons in the brain, which are in charge of basic muscle movement, are destroyed, causing paralysis or severe lack of muscle control. The phase I clinical study is investigating the use of mesenchymal stem cells (MSCs), known for their ability to support neural growth and survival, to prevent the premature neuron degradation normally associated with ALS, and/or their ability to slow the progression of the disease.

 

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Topics: ALS, Lou Gehrig's Disease, neural regrowth, mesenchymal stem cells

Stem Cell’s Regenerative Capabilities Sustained With Proteins

Posted by anna@stemsave.com on Feb 7, 2017 12:00:00 AM

 

 

Wan-Ju Li and Tsung-Lin Tsai, researchers at the University of Wisconsin-Madison, have developed a more efficient method to regrow large masses of bone. Using the proteins lipocalin-2 and prolactin, the researchers were able to slow and neutralize senescence, a naturally occurring process that negatively impacts the ability of stem cells to divide and grow, thereby preserving the regenerative capabilities of the mesenchymal stem cells and facilitating bone growth. The combination of these two proteins in culture provides sustenance for the stem cells to remain in prime condition until they are ready to be implanted into the patient.

 

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Topics: preserving stem cells, regenerative medicine, bone marrow, bone regrowth, bone repair

3D-Printed Bone Using Stem Cells

Posted by anna@stemsave.com on Dec 29, 2016 5:00:00 PM

A team of researchers at the University of Glasgow are utilizing 3D printers to create bone scaffolds that, when coated with a growth substance and stem cells, will continue to grow into bone in the implanted body. The aim of utilizing synthetically grown bone replacements is to create a readily available technology that can be used around the world, especially in places abundant with landmines. This is an important breakthrough for landmine blast survivors whose only option is usually amputation.

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Topics: 3D Printing, bone scaffolding, regenerative medicine, biological alternatives

Dental Stem Cells Advance Understanding of Autism

Posted by anna@stemsave.com on Dec 5, 2016 4:31:11 PM

 

Neurobiologists are utilizing dental stem cells from the pulp of baby teeth to study Autism Spectrum Disorder (ASD). Dental stem cells are very plastic stem cells [they can be differentiated into many types of tissue] derived from the neural crest during early embryonic development.

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Topics: autism, dental pulp, stem cells, cell-reprogramming, Autism Spectrum Disorder, regenerative medicine

Brain Damage Repair with Stem Cells

Posted by anna@stemsave.com on Jul 27, 2016 1:52:25 PM

Rachel Okolicsanyi, a scientist from the Genomics Research Centre at QUT’s Institute of Health and Biomedical Innovation, is manipulating mesenchymal stem cells [MSCs] to produce neural cells which can be used to treat brain damage. By introducing different chemicals to specific proteins found in stem cells, researchers can determine which chemicals facilitate, or prohibit, their potential to differentiate into neural cells. This advancement in the understanding of how stem cells can be directed will accelerate the development of treatments for brain damage, specifically from strokes and trauma.

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Topics: stem cells, brain damage repair, neural cells, genomics research, mesenchymal stem cells

Printing Organs with Stem Cells

Posted by anna@stemsave.com on Jul 15, 2016 4:01:27 PM

Researchers at the U.K’s University of Bristol’s School of Cellular and Molecular Medicine announced a new advancement in bio-printing. They developed a bio-ink that is comprised of stem cells and two polymers – one naturally occurring and the other artificial. The polymers provide structural support to the stem cells that can then be directed to differentiate into the appropriate tissue. The addition of the phase-change polymer component to the bio-ink allows the printed organ to quickly develop the structural integrity necessary to introduce cell nutrients to the stem cells.

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Topics: 3D Printing, bio-ink, stem cells, printing organs, bio printing, Stem Save

How Can You Mend a Broken Heart - with Stem Cells!

Posted by anna@stemsave.com on May 18, 2016 1:57:00 PM

With a nod to the Bee Gees - Scientists from the University of Utah School of Medicine have successfully treated heart failure patients with autologous stem cells. Patients with stem cell therapy experienced 37% fewer cardiac events--including death and hospital admissions--than a placebo group.

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Topics: stemsaveblog, cardiac arrest, bone marrow, Ischemic Cardiomyopathy, mesenchymal stem cells, regenerative medicine, autologous stem cells

Parkinson’s Disease Controlled by Stem Cells

Posted by anna@stemsave.com on Feb 23, 2016 1:38:00 PM

Parkinson’s disease is a progressive, degenerative disorder of the nervous system that affects more than 60,000 Americans each year. A group of researchers from Yonsei University in South Korea has discovered that the protection of nervous tissue may be facilitated by stem cells. Animals with Parkinson’s were injected with human mesenchymal stem cells. The treatment improved the animals’ cognitive behavior and suppressed alpha-synuclein, a toxic protein in the brain.  

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Topics: parkinsons disease, stemsaveblog, stem cell therapies, neurons, mesenchymal stem cells

Retinitis Pigmentosa Stem Cell Protocol Goes into Clinical Trials

Posted by anna@stemsave.com on Nov 5, 2015 2:03:00 PM

Dr. Henry Klassen of UC Irvine has initiated an FDA approved stem cell based clinical trial for the treatment of Retinitis Pigmentosa (RP) through the regeneration of damaged retinal tissue. RP is caused by the slow decay of photoreceptors in the retina, which provide vital chemical communication to the brain. The disease is thought to derive from mutations in genes responsible for rods and cones, which ultimately lead to blindness. There is no current treatment for RP.

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Topics: stemsaveblog, Retinitis Pigmentosa, Eyes, clinical trial, retinal blindness, mesenchymal stem cells

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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