A research team from the Stem Cell Engineering Center of the Translational Chinese Medicine has developed a method for repairing lungs afflicted with interstitial fibrosis utilizing autologous [the patient’s own] stem cells. The team recovered stem cells from the patient, cultured them in-vitro [outside the body] and then reintroduced them into the patient to repair the damaged lung tissue. The use of the patient’s own stem cells virtually eliminated the likelihood the patient would reject the treatment.
The 21st Century Cures Act [aka: the Cures Act], was passed by the Senate [95-4] and the House of Representatives [392-26] and signed into law by the President in December 2016. In addition to increasing funding for medical research, the act creates an accelerated pathway for the development of regenerative treatments. The Act provides new guidelines to enable the FDA to fast track clinical trials and streamline the approval process for regenerative therapies.
Each year, the need for coats and cold weather wear is great. Once again, StemSave is joining the NYC Police Department, Time Warner, Toshiba, NBC, Health Plus, Vornado and other concerned organizations and corporate citizens to serve our community and neighbors. StemSave is partnering up with the New York Cares organization for its 28th Annual Coat Drive to collect coats and outerwear from December 1st through December 31st. If you are in the area please feel free to stop by StemSave’s corporate headquarters located at 526 W. 26th St, Suite #622 in NYC (Monday-Friday 9am-5pm) to donate any new or gently used coats and outerwear. Thank you all in advance!
When stem cells are taken out of the body and placed in cultures, the microenvironment that permits the generation of an extracellular matrix is lost, impacting their functionality. To address this shortcoming, a team of researchers from A*STAR Institute of Medical Biology - led by Michael Raghunath and Cedric Badowski, in conjunction with scientists at the National University of Singapore utilized a technique termed 'macromolecular crowding’ [that mimics the microenvironment of the cells] to encourage stem cell differentiation and regeneration.
Dr. Mildred C. Embree and her team at the Columbia College of Dental Medicine have discovered stem cells that can facilitate the growth of cartilage and repair damaged joints. The fibrocartilage found in the temporomandibular joint (TMJ) in the jaw bone does not readily regrow or heal itself – hence, researchers worked to manipulate the stem cells that reside in the TMJ to regenerate cartilage and repair the joint.
Researchers at Johns Hopkins Kimmel Cancer Center have developed a system that uses differentiated human stem cells to expedite the testing of existing drugs that might work against rare cancers. By transforming human stem cells into an aggressive form of pediatric brain cancer, medulloblastoma, they can be compared to cancer cells already tested against existing drugs.
Researchers from Harvard University have developed a new growth medium which facilitates the transfer of intact stem cell sheets. Stem cell transplantation is most effective as a coherent surface, rather than a matrix of freely floating cells. Previous attempts to release intact cell sheets have relied on thermal denaturation, which affect transplant efficiency. Slippery Liquid-Infused Porous Surfaces (SLIPS) circumvent this problem by reversibly inducing slipperiness in a cell culture.
Doctors from the Melbourne Stem Cell Center are using stem cells to regrow damaged knee cartilage. Over 70 patients have had their own isolated and expanded mesenchymal stem cells (MSCs) injected into their own knee joints. In initial results, half of those treated at Melbourne Stem Cell Center saw a three-quarters reduction in pain and vastly improved knee function.
A recent article in the NY Times served to highlight the progress the medical community is making in combating genetic disorders.
The development of Crispr-Cas9 gene editing technology is profoundly altering the way the medical community is approaching the treatment of genetic disorders. By enhancing accuracy and simplifying the process for the removal and insertion of specific genes in the DNA sequence, Crispr-Cas9 has brought gene therapy back to the forefront of research in the treatment of genetic disorders.To no surprise, one of the key components of this treatment approach are stem cells.
The therapeutic efficacy of mesenchymal stem cell therapy has been extensively demonstrated and studied, leading to promising successes. Current applications include: immunosuppression of T-cells, the regeneration of blood vessels, assisting in skin wound healing, and suppressing chronic airway inflammation in asthma cases. However, when MSCs are being prepared for therapeutic application, they are often cultured in fetal bovine serum—which may result in unknown biochemical effects, which can lead to inconsistent outcomes. Now, a team of researchers from Singapore has developed a serum-free cell culture, which supports cellular growth, enhances consistency and increases the potential for greater efficacy in mesenchymal stem cell therapy.