Researchers at Cincinnati Children’s Hospital Medical Center Heart Institute have discovered a possible method of directing stem cells to fuse together and form functional skeletal muscle. Utilizing gene therapy, their research has provided insight into correcting disorders like muscular dystrophy, and congenital and metabolic myopathy. By identifying the genes Gm 7325 and Tmem8c, as well as their corresponding proteins, researchers have determined their paired role in directing muscle stem cells (myoblasts) in fusing and creating functional striated muscle tissue, which is responsible for movement.
Testing on mouse subjects, the researchers used gene editing technology to work in reverse and identify these genes’ role in muscle formation by turning them off. “The fusion technology possibly could be harnessed to provide muscle cells with a normal copy of the missing gene,” says Dr. Douglas Millay, senior researcher at Cincinnati Children’s Hospital’s Division of Molecular Cardiovascular Biology.
With clinical trials soon underway, this advancement in bioengineering will accelerate this trend and broaden applications to treat a wider variety of tumors. By banking their own valuable stem cells, families can ensure that they will have access to these emerging therapies in the near future. To learn more about banking stem cells, please visit StemSave or call 877-783- 6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
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