Researchers at the Salk Institute have developed a method to reprogram stem cells in skin ulcers and sores to differentiate into epithelial (skin) cells. The treatment advance has the potential to revolutionize treatment options for patients suffering from chronic skin conditions such as epidermolysis bullosa, ulcers and sores due to diabetes, bedsores and severe burns. Typically, there is an abundance of stem cells at the site of wounds such as ulcers. However, the stem cells prioritize dealing with inflammation and infection over the regeneration of skin tissue. The researchers sought to reprogram wound-resident mesenchymal stem cells in vivo [inside the body] by applying transduction factors, which directed the stem cells to generate skin tissue. Hence, the treatment is designed to generate new skin at the site of the wound as opposed to the current approach of utilizing a skin graft.
"This knowledge might not only be useful for enhancing skin repair but could also serve to guide in vivo regenerative strategies in other human pathological situations, as well as during aging, in which tissue repair is impaired,” comments lead researcher Dr. Izpisua Belmonte regarding the implications of this study. In addition, the research advances the understanding of the differentiation mechanisms of mesenchymal stem cells.
Advances in stem cell based regenerative treatments are creating more effective treatment options for patients suffering from a wide variety of disease, trauma and injury. To learn more about stem cells, and how families can bank their own valuable stem cells by recovering the very powerful dental pulp stem cells during routine dental procedures; such as wisdom teeth extractions or the during the loss of baby teeth, visit StemSave or call 877-783-6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
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