Researchers at the University of Southern California (USC) School of Medicine have pinpointed the biological processes that lead to the differentiation of skin stem cells into follicles that grow hair. As people age, the ability to regenerate skin cells declines and therefore, the follicles produce less and less hair. Utilizing a combination of bioinformatics and molecular screenings, the researchers studied the differentiation of stem cells into hair follicles of newborn mice, honing in on genetic factors and environmental cell signals this process entails. The process was then successfully implemented when applied to adult mice that lacked hair by introducing the necessary factors that signal stem cells to differentiate into organoids that will grow hair.
” In the future, this work can inspire a strategy for stimulating hair growth in patients with conditions ranging from alopecia to baldness,” says lead stem cell researcher and professor of pathology at the USC School of Medicine, Cheng-Ming Chuong.
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