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ALS Phase III Clinical Trial Launched Using Stem Cells

Posted by anna@stemsave.com on Oct 2, 2017 4:45:00 PM

Phase III clinical trials for a stem cell based ALS treatment has been initiated.  ALS, or amyotrophic lateral sclerosis, is a disorder in which motor neurons in the body rapidly degenerate, and the treatment aims to prolong the survival rate of afflicted individuals by using autologous [the patient’s own] mesenchymal stem cells (the same stem cells found in teeth), which can be differentiated into fully-functioning neurons. The trials, to be conducted by BrainStorm Therapeutics, exploits the company’s proprietary technology [NurOwn], which utilizes mesenchymal stem cells. BrainStorm obtains these cells from the patient, expanding and differentiating the stem cells prior to application. The stem cells begin producing neurotrophic factors that facilitate neuronal growth and regeneration.

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Topics: ALS, stem cell treatments, patient's own mesenchymal stem cells, regenerative medicine

ALS Stem Cell Treatment Shows Promising Results

Posted by hunter@stemsave.com on Jul 27, 2017 3:30:00 PM

A phase III clinical trial utilizing autologous [the patient’s own] mesenchymal stem cells (MSCs) has begun, and could offer relief to the millions suffering from ALS. The study is being conducted by Brainstorm Cell Therapeutics with  a grant of $16 million from the California Institute for Regenerative Medicine [CIRM].Brainstorm has developed a proprietary method [called NurOwn] for inducing MSCs to secrete neurological growth factors, which exhibits the ability to perpetuate the life of neurons experiencing rapid degradation in ALS patients. In previous clinical trials the treatment demonstrated the ability to slow the progression of ALS immediately following the treatment. The new trial seeks to prolong these beneficial effects.

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Topics: ALS, Lou Gehrig's Disease, mesenchymal stem cells, autologous stem cells, regenerative medicine, neural regrowth

Treating ALS With Stem Cells

Posted by anna@stemsave.com on May 10, 2017 1:00:00 PM

Researchers at the Mayo Clinic are researching stem cell treatments for amyotrophic lateral sclerosis (ALS), the onset of which remains unknown and the cure for which has yet to be discovered. For patients with ALS, motor neurons in the brain, which are in charge of basic muscle movement, are destroyed, causing paralysis or severe lack of muscle control. The phase I clinical study is investigating the use of mesenchymal stem cells (MSCs), known for their ability to support neural growth and survival, to prevent the premature neuron degradation normally associated with ALS, and/or their ability to slow the progression of the disease.

 

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Topics: ALS, Lou Gehrig's Disease, neural regrowth, mesenchymal stem cells

Stem Cell Grants Combat Rare Pediatric Diseases

Posted by barb@stemsave.com on Apr 14, 2016 1:15:45 PM

University of California researchers are fighting a variety of rare pediatric diseases with stem cells. Funding provided by the California Institute for Regenerative Medicine will address fatal conditions such as severe combined immunodeficiency, Tay-Sachs and Sandhoff disease, along with diseases ranging from cancer to amyotrophic lateral sclerosis.

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Topics: ALS, stemsaveblog, cancer research, regenerative medicine, stem cells, tay-sachs, sanhoff

ALS Study Utilizes Stem Cells to Illuminate the Role of Astrocytes in Neurodegenerative Disease.

Posted by pamela@stemsave.com on Apr 18, 2015 11:41:00 AM

Researchers led by Dr. Su-Chun Zhang at the University of Wisconsin-Madison Waisman Center are utilizing stem cells in a pre-clinical trial to determine the role of human astrocytes in neurodegenerative diseases such as ALS, Huntington’s disease, and Rhett Syndrome.  The team found that, upon integration into the central nervous system, stem cell-derived astrocytes from patients with ALS replace the astrocytes of the host while disrupting motor function, as though the host also had ALS.

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Topics: ALS, neural stem cells, autologous dental pulp stem cells, Amyotrophic lateral sclerosis, Neurodegenerative disease, neurological disease,, astrocytes, stemsaveblog

Multiple Sclerosis Treatment Becomes Canada’s First MS Stem Cell Clinical Trial.

Posted by taylor@stemsave.com on Mar 5, 2015 8:37:17 AM

The University of Ottawa trial infuses MSCs to reduce inflammation in the central nervous systems of MS patients.

The Multiple Sclerosis Society of Canada has funded Canada’s first stem cell clinical trial to treat multiple sclerosis, conducted by researchers at the University of Ottawa. The trial, called MESCAMS [Mesenchymal Stem Cell Therapy for Canadian MS patients], will comprise MSC infusions to the central nervous system to utilize their ability to regulate autoimmune attacks and reduce inflammation in 40 MS patients.

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Topics: ALS, Phase III, neural stem cells, multiple sclerosis, Brain, clinical trials, Debilitating Diseases, Stemcells, autologousstemcells, Amyotrophic lateral sclerosis, Neurodegenerative disease, stemsaveblog

New York Times: The Eruption of Stem Cell Therapies.

Posted by taylor@stemsave.com on Sep 16, 2014 11:04:35 AM

Mr. Edgar Irastorza is one of thousands of people already benefiting from the progression of stem cell based therapies.

As reported on the front page of the New York Times Science section, clinical applications of stem cell based therapies are accelerating at a rate that will revolutionize the medical field in a matter of years. In the United States alone, there are currently over 4000 therapies in clinical trials for the treatment of heart disease, blindness, spinal cord injuries, diabetes, H.I.V., and other diseases, injuries, and traumas.

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Topics: Muscular Dystrophy, ALS, Parkinson's, Phase III, multiple sclerosis, Heart, Joints, Alzheimer's, burn injuries, Diabetes, Acute Myocardial Infarction, Brain, Heart Failure, clinical trials, Bone, Debilitating Diseases, Phase II, Arthritis, Stemcells, Teeth, autologousstemcells, cartilage, Amyotrophic lateral sclerosis, Brain Tumors, Blindness, stemsaveblog

ALS Research Capitalizes on Stem Cells.

Posted by pamela@stemsave.com on Sep 5, 2014 7:35:09 AM

A recent Mt. Sinai study for ALS is set to enter phase one clinical trials.

Researchers at the Cedars-Mt. Sinai Regenerative Medicine Institute, led by Dr. Robert H. Baloh, have devised a method to study and develop potential treatments for Amyotrophic Lateral Sclerosis [ALS] by utilizing patients’ stem cell-derived neurons. In an example of what is referred to as translational genomics, researchers extract autologous (the patient’s own) stem cells, correct the defective gene causing the disease, and then, in a potential treatment protocol, transplant the cells back into the patient to reverse neural degeneration.

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Topics: ALS, Phase III, neural stem cells, clinical trials, Debilitating Diseases, Stemcells, translational genomics, autologousstemcells, stemsaveblog

Motor Neuron Development Accelerated by New Stem Cell Technique

Posted by Kelsey StemSave on Apr 18, 2014 11:01:17 AM

A new procedure in differentiating stem cells will accelerate advances in treating neurological diseases.

A team of researchers at the University of Illinois led by doctors Fei Wang, Qiuhao Qu, and JianJun Cheng, have developed a fast and efficient technique for differentiating stem cells into motor neurons. The researchers added critical signaling molecules and growth factors to the cells much earlier than previous methods, resulting in twice the amount of neurons derived from the cells in half the time.

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Topics: ALS, multiple sclerosis, Debilitating Diseases, Stemcells, autologousstemcells, spinal cord injuries, Amyotrophic lateral sclerosis, Neurodegenerative disease, stemsaveblog

Neural Stem Cells Reduce ALS Disease Progression in Mouse Model

Posted by anna@stemsave.com on Jan 16, 2013 8:10:06 AM

 

 

 

 

 

 

 

 

 

 

A consortium of researchers have successfully demonstrated that the transplantation of neural stem cells in the spinal cord of an ALS mouse model can slow the disease onset and progression, as well as improve motor function and significantly prolong the lifetime of the diseased agent.

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Topics: ALS, stemsaveblog

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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