Researchers at South Korea’s Ulsan National Institute of Science and Technology have developed a new scaffolding technique that speeds up stem cell differentiation for bone formation. Utilizing carbon nitride sheets infused with stem cells, the researchers were able to regenerate bone. The carbon nitride sheets possessed photocatalytic properties, which facilitated bone growth. This study marks an important advancement in treatments for bone fractures and periodontal disease.
Osteoporosis, a chronic and life-threatening degenerative disease, affects more 200 million globally, and with a growing population of aging adults projected to live longer lives than in generations past, the issue of preserving and protecting skeletal bone integrity will likely become increasingly important. A group of researchers from the Cedars-Sinai Medical Center have examined the relationship of therapeutic stem cell therapies in the complex endocrine system of animals with vertebral fractures, who received daily injections of parathyroid hormone(PTH) and stem cells for 21 days. The authors hypothesize that the combination of approaches enhanced the stem cell’s migration to damaged bone areas.
"We have known that used separately, both the stem cells and the hormone each have an effect on the healing process involved in bone fractures," said Dan Gazit, DMD, PhD, co-director of the Skeletal Regeneration and Stem Cell Therapy Program in the Department of Surgery and Cedars-Sinai Board of Governors Regenerative Medicine Institute. "Now, we have learned that the stem cells and PTH much stronger combined than they are separately."