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Osteoporosis Reversed Using Stem Cells

Posted by pamela@stemsave.com on Jul 27, 2015 2:45:25 PM

For over 10 million Americans, osteoporosis presents a chronic, degenerative, and complex problem, with few current therapeutic options to promote bone growth.  A team of researchers from Loma Linda University and the Jerry L. Pettis Memorial VA Medical Center in California have reversed the bone-degrading disease of osteoporosis in an animal model using hematopoietic stem cells [HSCs]. The research offers yet another development in our current understanding and capability for practical application in the stem cell field. Now, after having identified specific growth factors related to bone growth and proliferation, stem cell therapy is thought to holds great promise in reversing bone weakness and ultimately, morbidity and mortality.

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Topics: osteoporosis, Bone loss, stemsaveblog, hematopoietic stem cells, growth factors

Under Pressure – Stem Cell Differentiation Triggered by Mechanical Force.

Posted by pamela@stemsave.com on Apr 2, 2015 11:12:16 AM

Bioengineers from the University of California, San Diego, have identified a mechanism by which stem cell differentiation is regulated by the exertion of mechanical pressure.  Using optical tweezers to apply mechanical force to stem cells, the researchers, led by Dr. Yingxiao Wang, observed the release of calcium ions, which are critical in the cellular communication required for stem cell differentiation.  Dr. Wang’s team concluded that the forces of a stem cell’s environment, such as the tension inside the jaw, can promote the cell’s maturation into stiff tissue like bone or cartilage.

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Topics: Bone loss, stemsaveblog, Bone, repair cartilage, bone regeneration, stem cell differentiation, University of California San Diego, mechanical pressure,, pressure, calcium,

Tipping the Scales: Stem Cells May Help Prevent Obesity and More.

Posted by hunter@stemsave.com on Mar 12, 2015 8:18:00 AM

 

Scientists have found that the alteration of stem cell cilia can have a positive effect on weight loss.

 

In a recently published study from the Queen Mary University of London, scientists discovered a connection between the length of cilia [hair-like projections for cell movement] on stem cells and their proclivity towards differentiating into fat cells. By restricting the elongation of stem cell cilia, the researchers were able to impede on the formation of new fat cells.

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Topics: Eye, Bone loss, Bone, Debilitating Diseases, kidney, Stemcells, autologousstemcells, Blindness

Bone Regeneration Made Possible With Stem Cells

Posted by devin@stemsave.com on Mar 8, 2015 5:20:22 AM

Epibone creates precisely measured scaffolding for stem cells to recreate damaged bone.

The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone.

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Topics: osteoporosis, limbs, Fingers, Jaw, Bone loss, stemsaveblog, Joints, Bone, Debilitating Diseases, Arthritis, Stemcells, Knee, hip, autologousstemcells, cartilage, grants, Mandibular bone, young stem cells

Bone Regeneration Technique Stimulates Stem Cells with Magnetic Nanoparticles.

Posted by taylor@stemsave.com on Dec 28, 2014 10:55:40 AM

Remote controlled nanoparticles may allow stem cells to regenerate bone tissue

Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field.

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Topics: osteoporosis, Bone loss, stemsaveblog, knee replacement, Bone, Debilitating Diseases, Stemcells, Hip replacement, autologousstemcells, Cartilage degradation, spinal cord injuries

Osteoarthritis Stem Cell Treatment in Clinical Trial

Posted by anna@stemsave.com on Sep 16, 2014 6:55:33 AM

The transplantation of stem cells into areas affected by osteoarthritis allow lost cartilage tissue to regenerate.

In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis. The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue.

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Topics: osteoporosis, Fingers, Phase III, Bone loss, stemsaveblog, Joints, knee replacement, clinical trials, Bone, Debilitating Diseases, Arthritis, Stemcells, Feet, Rheumatoid Arthritis, Hip replacement, Knee, hip, autologousstemcells, cartilage, Cartilage degradation

Stem Cells Make a 'Dentin' Tooth Decay.

Posted by hunter@stemsave.com on Jun 17, 2014 9:39:44 AM

Researchers have utilized low-intensity lasers to regenerate lost dentin in damaged teeth.

Researchers at the National Institute for Dental and Craniofacial Research have developed a method of utilizing autologous [the patient’s own] dental stem cells to regenerate damaged or decayed teeth. In an animal model, as well as human cells in vitro [in a lab], the scientists treated the damaged teeth with low-intensity lasers, which prompted the stem cells located in the dental pulp to differentiate and grow into new, healthy dentin tissue.

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Topics: tooth decay, Bone loss, stemsaveblog, Bone, Debilitating Diseases, Stemcells, Teeth, autologousstemcells, dental pulp stem cells

Hip Replacement Procedure Utilizes Autologous Stem Cells.

Posted by taylor@stemsave.com on Jun 12, 2014 9:23:21 AM

Scientists have utilized stem cells to aid in artificial hip replacement.

Doctors and Scientist at the Southampton General Hospital have successfully completed a hip transplant by using a titanium socket and a bone scaffold loaded with skeletal stem cells. The team, led by orthopedic surgeon Douglas Dunlap, 3D printed the titanium implant, and then added the bone graft filled with stem cells to the pelvis to encourage bone regrowth behind and around the metal replacement.

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Topics: limbs, Bone loss, stemsaveblog, Joints, clinical trials, Bone, Debilitating Diseases, Stemcells, Knee, hip, autologousstemcells

Bone Reconstruction Technique Utilizes Autologous Stem Cells

Posted by barb@stemsave.com on Feb 28, 2014 9:08:10 AM

Stem cells are allowing doctors to personalize treatments to repair damaged or diseased bone.

A team of medical researchers at Saint Luc University Clinic have developed a method of repairing bones utilizing autologous [the patient’s own] stem cells. The process involves harvesting the stem cells from the patient, differentiating the stem cells in-vitro to grow bone, pairing the cells with a scaffolding matrix and then molding the material to repair damaged or diseased bone within the patient.

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Topics: osteoporosis, Bone loss, stemsaveblog, Joints, clinical trials, Bone, Debilitating Diseases, Phase II, Stemcells, autologousstemcells

Osteogenesis Imperfecta Treatment with Mesenchymal Stem Cells

Posted by maxi@stemsave.com on Jan 24, 2014 8:50:00 AM

 

 Mesenchymal Stem Cell treatment has been shown to improve bone tissue formation in babies with osteogenesis imperfecta.

Researchers from Karolinska Institutet’s Department of Clinical Sciences have developed an application for mesenchymal stem cells [the same type found in Dental Stem Cells] to provide treatment for children born with osteogenesis imperfecta. The researchers utilized the unique properties of MSCs to facilitate and improve bone tissue formation through in utero transplantations.

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Topics: Bone loss, clinical trials, Bone, Stemcells, cartilage

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AAOMS - American Association of Oral and Maxillofacial Surgeons

 

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