Wan-Ju Li and Tsung-Lin Tsai, researchers at the University of Wisconsin-Madison, have developed a more efficient method to regrow large masses of bone. Using the proteins lipocalin-2 and prolactin, the researchers were able to slow and neutralize senescence, a naturally occurring process that negatively impacts the ability of stem cells to divide and grow, thereby preserving the regenerative capabilities of the mesenchymal stem cells and facilitating bone growth. The combination of these two proteins in culture provides sustenance for the stem cells to remain in prime condition until they are ready to be implanted into the patient.
preserving stem cells
With a nod to the Bee Gees - Scientists from the University of Utah School of Medicine have successfully treated heart failure patients with autologous stem cells. Patients with stem cell therapy experienced 37% fewer cardiac events--including death and hospital admissions--than a placebo group.
mesenchymal stem cells,
autologous stem cells
A new method of stem cell harvesting was developed by a group of Australian researchers. The technique is less invasive than current methods and reduces unwanted side effects. Existing harvesting procedures are lengthy and require injections of growth factors to boost stem cell numbers. Growth factors can cause unpleasant side effects like bone pain and spleen enlargement for some patients while other patients don’t respond well impacting stem cell recovery.
stem cell harvesting,
In a recently published study, a team of researchers led by Dr. Giovanni Mancardi from the University of Genoa conducted a phase II clinical trial to compare the effectiveness of conventional multiple sclerosis [MS] therapy to intravenous stem cell transplantation. Throughout the four year trial, the team found that, in addition to significantly decreasing disease progression and brain damage compared to MS drug mitoxantrone [MTX], the transplanted stem cells had migrated into the patients’ bone marrow and stimulated the generation of new, non-harmful immune cells, essentially resetting the immune system.
university of genoa,,
nerve stem cells,