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The Nerve of Them – Scientists Chronicle Transition of Stem Cells to Nerve Cells In Vivo.

Posted by anna@stemsave.com on Apr 16, 2015 12:08:00 PM

Scientists led by Mathias Hoehn at the Max Planck Institute for Metabolic Research have devised a novel method for documenting the process by which human stem cells transplanted into the cerebral cortex of an animal model develop into mature nerve cells.  The researchers inserted optical image reporters into the cells to emit different shades of light when certain genes were activated. By observing the sequence in which the light was emitted, the group determined the timeline of the stem cell’s transformation in vivo.

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Topics: parkinsons disease, neural stem cells, stemsaveblog, Brain, bank your stem cells, stroke recovery, nerve damage, neurons, Neurodegenerative disease

Multiple Sclerosis Treatment “Resets” Immune System through Stem Cell Transplantation.

Posted by maxi@stemsave.com on Apr 4, 2015 11:36:00 AM

In a recently published study, a team of researchers led by Dr. Giovanni Mancardi from the University of Genoa conducted a phase II clinical trial to compare the effectiveness of conventional multiple sclerosis [MS] therapy to intravenous stem cell transplantation.  Throughout the four year trial, the team found that, in addition to significantly decreasing disease progression and brain damage compared to MS drug mitoxantrone [MTX], the transplanted stem cells had migrated into the patients’ bone marrow and stimulated the generation of new, non-harmful immune cells, essentially resetting the immune system.

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Topics: multiple sclerosis, stemsaveblog, Brain, clinical trials, clinical trial, bone marrow, immune system, neurological disease,, university of genoa,, autoimmune attack, nerve stem cells,

Cerebral Palsy Treatment Utilizes 2 Types of Autologous Stem Cells.

Posted by hunter@stemsave.com on Mar 31, 2015 10:41:58 AM

Researchers at the University Hospital Niño Jesus in Madrid, Spain, are conducting a clinical trial to determine the safety and efficacy of treating cerebral palsy patients with hematopoietic stem cells from cord blood, as well as mesenchymal stem cells [MSCs] from umbilical cord tissue.  The scientists will compare the two types of autologous [the patient’s own] stem cells in their effectiveness regarding immune-regulation, anti-inflammatory activity, and stimulation of brain tissue regeneration.

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Topics: stemsaveblog, Brain, 'infantile' cerebral palsy, cerebral palsy, cord blood, clinical trial, Stem Cells Translational Medicine

Multiple Sclerosis Treatment Becomes Canada’s First MS Stem Cell Clinical Trial.

Posted by taylor@stemsave.com on Mar 5, 2015 8:37:17 AM

The University of Ottawa trial infuses MSCs to reduce inflammation in the central nervous systems of MS patients.

The Multiple Sclerosis Society of Canada has funded Canada’s first stem cell clinical trial to treat multiple sclerosis, conducted by researchers at the University of Ottawa. The trial, called MESCAMS [Mesenchymal Stem Cell Therapy for Canadian MS patients], will comprise MSC infusions to the central nervous system to utilize their ability to regulate autoimmune attacks and reduce inflammation in 40 MS patients.

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Topics: ALS, Phase III, neural stem cells, multiple sclerosis, stemsaveblog, Brain, clinical trials, Debilitating Diseases, Stemcells, autologousstemcells, Amyotrophic lateral sclerosis, Neurodegenerative disease

Stroke-Induced Brain Damage Prevented by Stem Cells.

Posted by barb@stemsave.com on Feb 17, 2015 8:35:58 AM

Stem cells have been found to prevent neurological damage to GCI stroke victims.

In a recently published study from the Hallym University College of Medicine, researchers have applied mesenchymal stem cells [MSCs] to animal models afflicted with global cerebral ischemia [GCI] to successfully reduce the associated neuronal damage. When compared to those that received no treatment, animals that received MSCs displayed a significant decrease in cell death, inflammation to the brain, and disruption of the blood brain barrier.

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Topics: neural stem cells, stemsaveblog, stroke, Brain, clinical trials, Debilitating Diseases, Stemcells, autologousstemcells

Sniffing Out Parkinson’s Disease with Stem Cells

Posted by taylor@stemsave.com on Jan 29, 2015 9:36:21 AM

Stem Cells found in the nose produce neurons that may be able to treat neurodegenerative diseases.

German scientists at the University of Bielefeld and Dresden University of technology have produced neurons from inferior turbinate stem cells [ITSC], a cell type that is typically discarded during sinus surgery, as a potential treatment for Parkinson’s disease. After transplanting the ITSCs into an animal model suffering from Parkinson’s, the researchers observed full functional restoration and significant behavioral recovery in the subjects without any adverse side effects.

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Topics: nose, Parkinson's, stemsaveblog, Brain, Debilitating Diseases, Stemcells, autologousstemcells, Neurodegenerative disease

Multiple Sclerosis Trial Exhibits Positive Results of Stem Cell Therapy.

Posted by barb@stemsave.com on Jan 23, 2015 6:14:37 AM

A five year phase II clinical trial has shown initial success in treating multiple sclerosis.

In a recent update of an ongoing five year clinical trial conducted by the Chicago Blood Cancer Institute, patients with relapsing-remitting multiple sclerosis have experienced suppression of disease-related inflammation as a result of hematopoietic stem cell transplantations. The stem cells have the ability to regulate the autoimmune attack on the central nervous system, and have provided 82.8% of the patients with two years thus far of event-free disease remission.

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Topics: Phase III, neural stem cells, multiple sclerosis, stemsaveblog, Brain, clinical trials, Debilitating Diseases, Phase II, Stemcells, autologousstemcells

The Nose Knows - The Importance of Stem Cells.

Posted by anna@stemsave.com on Nov 14, 2014 9:06:04 AM

Stem cells are regulators for critical connections between the nose and the brain.

Scientists from the National Institute of Neurological Disorders and Stroke have identified neural stem cells as important regulators of the olfactory bulb and its connections to the brain. The researchers discovered that a constant influx of stem cells is required for the olfactory system to function properly. The removal of stem cells causes a widespread disruption of signals sent to the brain, resulting in sensory deprivation.

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Topics: nose, neural stem cells, stemsaveblog, Brain, Debilitating Diseases, Stemcells, autologousstemcells, young stem cells

Singing the Praises of Stem Cell Research

Posted by taylor@stemsave.com on Oct 25, 2014 6:30:15 AM

Stem Cells in white crown sparrows used to study neurodegenerative diseases.

A research team from the University of Washington has discovered a stem cell signal in Gambel’s white-crown sparrows that may lead to new regenerative treatments for patient suffering from neurodegenerative diseases. The team found that, in preparation for an upcoming mating season, the sparrow’s brain cells release a chemical signal that activates the division of neural stem cells, which facilitate peak singing performance to attract mates.

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Topics: neural stem cells, stemsaveblog, Alzheimer's, Brain, Debilitating Diseases, Stemcells, autologousstemcells, Neurodegenerative disease

Brain Tumor Chemotherapy Delivered via Stem Cells.

Posted by barb@stemsave.com on Oct 22, 2014 5:20:31 AM

Scientists hope to use stem cells to minimize collateral damage from brain tumor chemotherapy treatments.

Neuroscientist Dr. Karen Aboody, M.D. and Oncologist Dr. Jana Portnow, M.D. from City of Hope Hospital are set to begin a phase 1 clinical trial for a method of delivering chemotherapy treatments to glioblastoma [aggressive brain tumors] with modified neural stem cells. The scientists plan to capitalize on the stem cells’ innate ability to seek out invasive tumors by loading the cells with a chemotherapeutic protein and then injecting them into the brain.

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Topics: neural stem cells, stemsaveblog, Brain, Debilitating Diseases, Stemcells, autologousstemcells, Brain Tumors

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AAOMS - American Association of Oral and Maxillofacial Surgeons

 

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