We all take articular cartilage for granted. It takes up a seemingly insignificant amount of space, and somehow absorbs the full pressure our body weight. Arthritis and articular injuries can cause chronic and crippling pain. One group of researchers is developing 3D printed cartilage by bioprinting with an ‘ink’ containing human cells. This technology may one day lead to printed implants, noses, ears, and knees.
Scientists from the University of California Los Angeles have identified the origins cells of human articular cartilage. Cartilage loss is at the forefront of American medicine, with osteoarthritis currently affecting more than 20 million people in the US. This experiment could serve as a biological roadmap for regenerative therapies repairing cartilage defects and damage.
The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone.
Topics: osteoporosis, limbs, Fingers, Jaw, Bone loss, Joints, Bone, Debilitating Diseases, Arthritis, Stemcells, Knee, hip, autologousstemcells, cartilage, grants, Mandibular bone, young stem cells, stemsaveblog
As reported on the front page of the New York Times Science section, clinical applications of stem cell based therapies are accelerating at a rate that will revolutionize the medical field in a matter of years. In the United States alone, there are currently over 4000 therapies in clinical trials for the treatment of heart disease, blindness, spinal cord injuries, diabetes, H.I.V., and other diseases, injuries, and traumas.
Topics: Muscular Dystrophy, ALS, Parkinson's, Phase III, multiple sclerosis, Heart, Joints, Alzheimer's, burn injuries, Diabetes, Acute Myocardial Infarction, Brain, Heart Failure, clinical trials, Bone, Debilitating Diseases, Phase II, Arthritis, Stemcells, Teeth, autologousstemcells, cartilage, Amyotrophic lateral sclerosis, Brain Tumors, Blindness, stemsaveblog
In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis. The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue.
Topics: osteoporosis, Fingers, Phase III, Bone loss, Joints, knee replacement, clinical trials, Bone, Debilitating Diseases, Arthritis, Stemcells, Feet, Rheumatoid Arthritis, Hip replacement, Knee, hip, autologousstemcells, cartilage, Cartilage degradation, stemsaveblog
A research team led by Doctor Alexander Seifalian at University College London is currently creating custom lab-grown organs and body parts for patients utilizing autologous [the patient’s own] stem cells. The scientists have engineered a polymer material that they mold into the shape of an organ in need, infuse with the patient’s stem cells, and then transplant back onto the patient’s body.
Researchers from Karolinska Institutet’s Department of Clinical Sciences have developed an application for mesenchymal stem cells [the same type found in Dental Stem Cells] to provide treatment for children born with osteogenesis imperfecta. The researchers utilized the unique properties of MSCs to facilitate and improve bone tissue formation through in utero transplantations.
Orthopedic Surgeons are utilizing autologous [the patient’s own] stem cells to treat injuries and degenerative diseases in the joints and bones of athletes. The treatments involve the recovery of the patient’s own mesenchymal stem cells - which are particularly plastic and can differentiate into a variety of tissue types and implanting them back into the damaged bone or joint to reduce inflammation and regenerate damaged tissue without the need for invasive surgery.
Cartilage injuries can range from small lesions, such as those of athletes, to chronic injuries, such as cartilage degradation. Cartilage injuries, which are difficult to repair and have limited options for surgery, and usually results in a drastic affect on quality of life of afflicted individuals. In addition, the health, number and vitality of cartilage cells diminish with age.