Scientists have found that the alteration of stem cell cilia can have a positive effect on weight loss.
In a recently published study from the Queen Mary University of London, scientists discovered a connection between the length of cilia [hair-like projections for cell movement] on stem cells and their proclivity towards differentiating into fat cells. By restricting the elongation of stem cell cilia, the researchers were able to impede on the formation of new fat cells.
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Topics:
Eye,
Bone loss,
Bone,
Debilitating Diseases,
kidney,
Stemcells,
autologousstemcells,
Blindness
Epibone creates precisely measured scaffolding for stem cells to recreate damaged bone.
The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone.
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Topics:
osteoporosis,
limbs,
Fingers,
Jaw,
Bone loss,
stemsaveblog,
Joints,
Bone,
Debilitating Diseases,
Arthritis,
Stemcells,
Knee,
hip,
autologousstemcells,
cartilage,
grants,
Mandibular bone,
young stem cells
The University of Ottawa trial infuses MSCs to reduce inflammation in the central nervous systems of MS patients.
The Multiple Sclerosis Society of Canada has funded Canada’s first stem cell clinical trial to treat multiple sclerosis, conducted by researchers at the University of Ottawa. The trial, called MESCAMS [Mesenchymal Stem Cell Therapy for Canadian MS patients], will comprise MSC infusions to the central nervous system to utilize their ability to regulate autoimmune attacks and reduce inflammation in 40 MS patients.
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Topics:
ALS,
Phase III,
neural stem cells,
multiple sclerosis,
stemsaveblog,
Brain,
clinical trials,
Debilitating Diseases,
Stemcells,
autologousstemcells,
Amyotrophic lateral sclerosis,
Neurodegenerative disease
Dental Stem Cells may hold the potential to cure corneal blindness.
Ophthalmologists James L Funderburgh, Ph.D. and Fatima Syed-Picard, Ph.D. from the University of Pittsburgh have devised a method for treating corneal blindness by utilizing dental pulp stem cells. The researchers harvested the stem cells from molars discarded during routine extraction and induced the cells to differentiate into keratocytes [corneal cells]. They then seeded the cells onto a nanofiber scaffold, allowing them to grow into fully developed, functional corneas capable of restoring eyesight.
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Topics:
Eye,
stemsaveblog,
Debilitating Diseases,
Stemcells,
Teeth,
autologousstemcells,
dentalstemcells,
dental pulp stem cells,
Blindness
Stem cells may eliminate the need for painful skin grafts for burn victims.
In a new two year clinical trial conducted by the University of Miami, researchers will attempt to treat deep second degree burn victims with mesenchymal stem cells [MSCs] as a potential alternative to skin grafts. The team, led by Dr. Evangelos Badiavas, will first cover the wounds in protective dressing, and then inject the MSCs under the dressing and into the wounds to spur the regeneration of the inner and outer layers of skin.
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Topics:
Skin,
stemsaveblog,
burn injuries,
clinical trials,
Debilitating Diseases,
Stemcells,
autologousstemcells
Initial trials of stem cell treatment for hypoplastic left heart syndrome have proven to be both safe and effective for children with the congenital defect.
Researchers from Okayama University have developed a method to treat the congenital heart defect known as hypoplastic left heart syndrome [HLHS] by utilizing a specialized cardiac stem cell. In a Phase I clinical trial conducted on children suffering from HLHS, the scientists concluded that, because the young stem cells in children are more abundant and self-renewing than those in adults, intracoronary injection of stem cells is a safe and feasible approach to treating the condition.
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Topics:
Heart Valve,
Phase III,
Heart,
stemsaveblog,
Heart Failure,
Pediatric Congenital Heart Disease,
clinical trials,
Debilitating Diseases,
Stemcells,
hypoplastic left heart syndrome,
Heart Attack,
autologousstemcells,
heart disease
Stem cells have been found to prevent neurological damage to GCI stroke victims.
In a recently published study from the Hallym University College of Medicine, researchers have applied mesenchymal stem cells [MSCs] to animal models afflicted with global cerebral ischemia [GCI] to successfully reduce the associated neuronal damage. When compared to those that received no treatment, animals that received MSCs displayed a significant decrease in cell death, inflammation to the brain, and disruption of the blood brain barrier.
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Topics:
neural stem cells,
stemsaveblog,
stroke,
Brain,
clinical trials,
Debilitating Diseases,
Stemcells,
autologousstemcells
MSCs and HCELL molecules track down islet cells and reverse inflammation.
According to a recently published study from the Brigham and Woman’s Hospital, mesenchymal stem cells [MSCs] have the ability to reverse type I diabetes by suppressing the auto-immune attack of islet cells. Although the MSCs cannot be directly injected into the pancreas, the researchers utilized the surface adhesion molecule HCELL to hone the stem cells in on the inflamed islets, allowing them to normalize blood sugar levels without the use of insulin.
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Topics:
stemsaveblog,
Diabetes,
Type-1 Diabetes,
Debilitating Diseases,
Stemcells,
autologousstemcells
Stem cells were found to reduce plaque in patients with atherosclerosis.
According to new research from the National Yang-Ming University, mesenchymal stem cells [MSCs] hold the ability to limit atherosclerotic plaque formation, thereby preventing the onset of harmful endothelial lesions. The research team, led by Shih-Chieh Hung, transplanted MSCs into animal models with atherosclerosis and observed significant reduction in plaque formation. They also saw an increase in blood vessel dilation, which prevents further plaque development, indicating good endothelial health.
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Topics:
Artery,
limbs,
Heart,
stemsaveblog,
Heart Failure,
Debilitating Diseases,
Stemcells,
autologousstemcells,
Blood vessel,
Peripheral Arterial Disease
Stem Cells found in the nose produce neurons that may be able to treat neurodegenerative diseases.
German scientists at the University of Bielefeld and Dresden University of technology have produced neurons from inferior turbinate stem cells [ITSC], a cell type that is typically discarded during sinus surgery, as a potential treatment for Parkinson’s disease. After transplanting the ITSCs into an animal model suffering from Parkinson’s, the researchers observed full functional restoration and significant behavioral recovery in the subjects without any adverse side effects.
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Topics:
nose,
Parkinson's,
stemsaveblog,
Brain,
Debilitating Diseases,
Stemcells,
autologousstemcells,
Neurodegenerative disease