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StemSave Blog

Stem Cell Implant to Treat Cardiomyopathy

Posted by pamela@stemsave.com on Jul 14, 2018 4:36:00 PM

A Phase I clinical trial has been approved to assess the efficacy of a stem cell graft procedure that seeks to provide a more robust treatment option for  the millions of individuals who suffer from cardiomyopathy. Cardiomyopathy is a disease which affects cardiac muscle, making it extremely difficult to for the heart to pump blood, straining and wearing down the cardiac muscles further. Prolonged cardiomyopathy can require surgical intervention, and in severe cases, a heart transplant. By implanting a thin membrane of collagen scaffold – seeded with the patient’s own stem cells, over the affected area, the stem cell graft changes the status quo on cardiomyopathy treatments by allowing the damaged heart muscle to mend itself. While current surgical treatments lack long-term efficacy in clinical applications, this novel approach was developed to specifically concentrate the stem cells to the site of the damaged tissue thereby increasing cellular repair and survival.

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Topics: cardiomyopathy, Ischemic Cardiomyopathy, heart disease, stem cell graft

Stem Cells Utilized to Treat HLHS

Posted by pamela@stemsave.com on Dec 27, 2016 4:00:00 PM

Researchers at the University of Maryland Medical Center are developing a stem cell treatment that can be utilized to treat hypoplastic left heart syndrome (HLHS) in children. By taking a new approach to make the right side of the heart stronger instead of replacing the damaged left side, researchers hope to engender a more permanent fix. The procedure would represent a significant advancement over current HLHS treatments; which include heart transplants and reconstructive procedures that only provide temporary relief.

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Topics: hypoplastic left heart syndrome, stem cell treatments, regenerative therapies, HLHS, heart disease

Wearing Your Heart on a Chip – Stem Cells Create Functional Heart Cells In Vitro.

Posted by devin@stemsave.com on Apr 28, 2015 3:06:00 PM

Bioengineers from the University of California, Berkeley, have utilized adult stem cells to create a network of pulsating heart cells encased in a silicon chip, effectively modeling cardiac tissue.  To capture the dynamic structure and function of the heart, the scientists loaded the stem cells into a layered, 3-D scaffold to mimic the geometry of the organ and included channels on either side of the chip to act as blood vessels, thus replicating the organ’s natural exposure to nutrients and therapies.

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Topics: Heart, cardiac stem cells, Heart Attack, regenerative therapies, disease-on-a-chip, blood vessels, heart disease, research, StemSave, banking your own stem cells, organs, regenerative medicine, stem cells

Hypoplastic Left Heart Syndrome Treatment Integrates Cardiac Stem Cells.

Posted by anna@stemsave.com on Feb 21, 2015 9:09:04 AM

Initial trials of stem cell treatment for hypoplastic left heart syndrome have proven to be both safe and effective for children with the congenital defect.

Researchers from Okayama University have developed a method to treat the congenital heart defect known as hypoplastic left heart syndrome [HLHS] by utilizing a specialized cardiac stem cell. In a Phase I clinical trial conducted on children suffering from HLHS, the scientists concluded that, because the young stem cells in children are more abundant and self-renewing than those in adults, intracoronary injection of stem cells is a safe and feasible approach to treating the condition.

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Topics: Heart Valve, Phase III, Heart, Heart Failure, Pediatric Congenital Heart Disease, clinical trials, Debilitating Diseases, Stemcells, hypoplastic left heart syndrome, Heart Attack, autologousstemcells, heart disease, stemsaveblog

Muscular Dystrophy-Induced Heart Failure Averted by Stem Cells.

Posted by devin@stemsave.com on Jan 2, 2015 7:59:49 AM

Although duchenne muscle dystrophy affects the entire body, often the cause of death for DMD patients is heart failure.

Researchers led by Eduardo Marbón of the Cedars-Sinai Heart Institute have developed a method to prolong the lives of patients with Duchenne Muscular Dystrophy [DMD] through the infusion of cardiac stem cells. The stem cells reverse the loss of cardiac muscle caused by the genetic disease, preventing heart failure that would otherwise limit a patient’s life expectancy to age 25.

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Topics: Muscular Dystrophy, Heart, Heart Failure, Duchenne Muscular Dystrophy, Debilitating Diseases, Stemcells, Heart Attack, autologousstemcells, heart disease, stemsaveblog

Stem Cells With a Heart of Gold.

Posted by devin@stemsave.com on Nov 5, 2014 5:42:47 AM

Scientists use gold nanoparticles to improve stem cell transplants for heart disease patients.

A team of bioengineers from Tel Aviv University is currently developing a scaffold to help regenerate heart muscle through the use of autologous stem cells. The scientists, led by Dr. Tal Dvir, aim to replace damaged cardiac tissue in heart attack patients by creating a scaffold out of collagen and gold nanoparticles, and then infusing it with the patient’s own stem cells to stimulate the rejuvenation of cardiomyocytes.

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Topics: Heart Valve, Heart, Acute Myocardial Infarction, Heart Failure, Debilitating Diseases, Stemcells, Heart Attack, autologousstemcells, heart disease, stemsaveblog

Barth Syndrome Studied Utilizing “Organ-On-A-Chip” Technology and Autologous Stem Cells.

Posted by devin@stemsave.com on Jun 5, 2014 10:20:21 AM

Scientists have generated heart tissue on a chip to better study Barth Syndrome.

A team of scientists from the Wyss Institute, Boston Children’s Hospital, and Harvard’s Medical School, Stem Cell Institute, and School of Engineering has created a model to study and develop treatments for the genetic heart disorder Barth Syndrome by utilizing a patient’s own stem cells in conjunction with an organ-on-a-chip. The chip was outfitted with proteins to mimic the cellular environment of the heart, causing the patient’s stem cells to differentiate into diseased heart tissue. The tissue was then studied to not only determine the cause of the disease, but to treat the diseased tissue as well.

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Topics: Heart Valve, Heart, Heart Failure, Debilitating Diseases, Stemcells, Heart Attack, autologousstemcells, heart disease, stemsaveblog

Heart Failure Treatment Utilizing Stem Cells.

Posted by devin@stemsave.com on Mar 6, 2014 12:29:16 PM

Columbia researchers have developed a scaffold that will allow stem cells to repair heart damage.

A team of researchers led by Dr. Gordana Vunjak-Novakovic [a member of StemSave’s Scientific Advisory Council has engineered a scaffold to facilitate the regeneration of heart muscle through the use of adult stem cells. In an animal model, Vunjak-Novakovic and her team created a scaffold using biodegradable chitosan and carbon nanofibers, infusing it with stem cells to provoke the regeneration of beating cardiomyocytes.

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Topics: Heart Failure, Debilitating Diseases, Stemcells, Heart Attack, autologousstemcells, heart disease, stemsaveblog

Stem Cell Treatment for Heart Damage Progresses to Phase 2 Clinical Trials

Posted by hunter@stemsave.com on Feb 23, 2014 9:27:56 AM

The progression of stem cell treatments is the only way to help the heart regenerate its own muscle.

Research teams from Cedars-Sinai Heart Institute and the Minneapolis Heart Institute with funding from CIRM [California Institute for Regenerative Medicine] are moving to Phase 2 Clinical Trials for a treatment that utilizes cardiac stem cells to repair severe heart damage. The treatment development was led by Eduardo Marbán, a director at the Cedars-Sinai Heart Institute and founder of Capricor. This groundbreaking treatment involves the injection of stem cells into the coronary artery, which then migrate to the heart and promote the regrowth of healthy heart muscle.

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Topics: Heart Valve, Phase III, Heart, Acute Myocardial Infarction, Heart Failure, clinical trials, Debilitating Diseases, Phase II, Stemcells, Heart Attack, autologousstemcells, heart disease, stemsaveblog

Heart Disease Treatment Utilizes Mesenchymal Stem Cells [MSCs]

Posted by pamela@stemsave.com on Jan 31, 2014 6:16:40 AM

Cell-Kro has the potential to rebuild damaged portions of the heart using the patient's own stem cells.

Researchers from the University of Vermont have developed a novel and effective application of mesenchymal stem cells [the same type found in Dental Stem Cells] to treat heart disease. The MSCs, when transplanted along with cardiac stem cells into the heart [in an animal model], produced a “cocktail” of protective ligands that improved the grafting success of the cardiac stem cells.

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Topics: Heart Valve, Heart, Heart Failure, clinical trials, Stemcells, Heart Attack, autologousstemcells, heart disease, stemsaveblog

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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