Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field.
In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis. The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue.
Topics: osteoporosis, Fingers, Phase III, Bone loss, Joints, knee replacement, clinical trials, Bone, Debilitating Diseases, Arthritis, Stemcells, Feet, Rheumatoid Arthritis, Hip replacement, Knee, hip, autologousstemcells, cartilage, Cartilage degradation, stemsaveblog
Researchers from the UNSW Graduate School of Biomedical Engineering, Ludwig Maximilians University, Case Western Reserve University, and the Cleveland Clinic have identified a source of autologous [the patient’s own] stem cells, called periosteum-derived stem cells [PDSC], which reside in the discarded tissue resulting from hip replacement surgery.
Arthritis affects 44 million individuals in the US resulting in the need for approximately 700,000 knee-replacement and 100,000 hip replacement surgeries every year. Researchers at Stanford University have developed a technique to track the effectiveness of mesenchymal stem cells [the type of stem cells found in teeth] in repairing arthritic joints. Mesenchymal stem cells are capable of differentiating into bone and cartilage, as well as muscle, fat and tendon. The researchers expect to adapt the study for clinical trials in humans this fall.