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Treating Pulmonary Fibrosis with Stem Cells

Posted by [email protected] on Jun 3, 2016 3:30:00 PM

Mesenchymal stem cells (MSCs) have been found to aid in the treatment of autoimmune-related lung fibrosis. Interstitial pneumonia is the inflammation of alveoli, and affects patients with pulmonary fibrosis and other connective tissue diseases. Increased fibrosis is due to an overactive immune response--mainly cytotoxic T cells. Past therapies have tried to suppress all immune cells to lower pro-fibrotic molecules. Mesenchymal stem cells are able to selectively change the composition of T cells from cytotoxic to regulatory. Bone marrow derived stem cells interfered with overactive autoimmune processes, and promoted the repair of alveoli tissue.

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Topics: stemsaveblog, autoimmune disease, inflammation, mesenchymal stem cells, connective tissue, pneumonia, lung fibrosis

Stem Cells Offset Septic Shock

Posted by [email protected] on May 16, 2016 1:52:00 PM

Sepsis is a systemic inflammatory response to severe infection, impairing metabolic function across all organ systems--affecting some 28 million people and claiming 8 million victims worldwide each year. Septic shock can lead to permanent neurological and muscular damage. Researchers at the Ottawa Hospital hope to change these statistics with an innovative therapy using injections of mesenchymal stem cells.

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Topics: stemsaveblog, organ failure, inflammation, immune system, mesenchymal stem cells, sepsis, personalized medicine

Sepsis Muscle Degradation Treatment Utilizes Mesenchymal Stem Cells

Posted by [email protected] on Feb 5, 2016 1:01:29 PM

Scientists from the Institut Pasteur have developed a novel therapeutic approach to sepsis that utilizes mesenchymal stem cell transplantation to restore muscle capacity. Sepsis is a systemic inflammatory response to severe infection, impairing metabolic function across all organ systems--affecting some 28 million people and claiming 8 million victims worldwide each year. Septic shock can lead to permanent neurological and musculatory damage. Mesenchymal stem cells can be easily cultured in the laboratory and are known for their immunomodulatory properties, which makes them an excellent option for cell therapy transplants that aim to repair degenerative or traumatic lesions.

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Topics: stemsaveblog, muscle, inflammation, stem cell transplant, Regenerative Biology and Tissue Engineering, sepsis

Stem Cells Undo Opioid Tolerance

Posted by [email protected] on Aug 21, 2015 1:41:00 PM

Researchers at the Cleveland Clinic reported that treating animal subjects with mesenchymal stem cells prevented opioid tolerance despite repeated exposure. Stem cells, when provided after opioid tolerance was established, essentially reversed both tolerance and hypersensitivity to pain associated with opioid tolerance. Although opioids like morphine are essential to the treatment of pain, tolerance requires the use of increasingly higher doses which carry potentially significant morbidity.

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Topics: stemsaveblog, inflammation, mesenchymal stem cells, morphine, pain management, opioid, chronic pain

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