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Stem Cells Differentiated into Intestinal Tissue

Posted by davids@stemsave.com on Nov 30, 2016 6:00:00 PM

Dr. Michael Helmrath, MD and Jim Wells, PhD of the Cincinnati Children’s Hospital Medical Center announced a significant advance in the differentiation of pluripotent stem cells into intestinal tissue with functional nerves. This milestone will enable the use of the cultured intestinal tissue to be used, in the short term, for drug testing and, in the longer term, for the development of regenerative treatments to address a myriad of intestinal disorders such as Irritable Bowel Syndrome, Intestinal Cancers and Hirschsprung’s disease.

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Topics: regenerative therapies, intestinal tissue, stem cells, pluripotent stem cells, Hirschsprung's disease

Feeling the Burn: Fat Loss Therapy Utilizes Stem Cells.

Posted by pamela@stemsave.com on Dec 22, 2014 10:07:47 AM

Scientists have identified two stimulants that induce stem cells to mature into brown fat cells instead of unhealthy white fat cells.

According to a recent study conducted by scientists at the Harvard Stem Cell Institute, stem cells may hold the key to replacing the body’s unwanted storage of white fat cells with calorie-burning brown fat cells. The researchers studied the stem cells that typically mature into white fat cells, and, after screening the effects of 1000 compounds on the cells, they found two that stimulate the stem cells to differentiate into brown fat cells instead.

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Topics: Skin, stemsaveblog, stomach, Debilitating Diseases, Stemcells, autologousstemcells, intestinal tissue, small intestine

Listen to Your Gut - “Mini-Stomachs” Built In-Vitro from Stem Cells.

Posted by anna@stemsave.com on Dec 19, 2014 10:29:32 AM

Scientists have engineered cellular clusters that mimic the functions of the stomach.

Scientists at the Cincinnati Children’s Hospital Medical Centre have induced adult stem cells to differentiate into small clusters of gastric tissue that replicate the functions of the human stomach. The lab-made structures, known as “mini-stomachs”, were created by replicating the chemical pathways of early stage stomach development of stem cells in a petri dish.

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Topics: stemsaveblog, Diabetes, stomach, Debilitating Diseases, Stemcells, Crohn's Disease, autologousstemcells, grants, cholangiocarcinoma, intestinal tissue

Stem Cells Grow Human Intestines Successfully

Posted by hunter@stemsave.com on Dec 1, 2014 8:03:44 AM

Scientists have engineered human intestinal tissue through the use of stem cells.

Researchers from the Cincinnati Children’s Hospital Medical Centre have successfully grown functional human intestinal tissues by utilizing stem cells. After stimulating the stem cells with a “molecular cocktail” of chemicals and growth factors, the team observed as the cells developed into the mucosal lining and muscle layers, while exhibiting digestive functions such as nutrient uptake and responding to molecular signals.

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Topics: Gastrointestinal cancer, stemsaveblog, ulcerative colitis, Debilitating Diseases, Stemcells, Crohn's Disease, Thanksgiving, autologousstemcells, intestinal tissue, small intestine, Inflammatory Bowel Disease

Researchers Develop Technique to Grow Intestinal Stem Cells

Posted by devin@stemsave.com on Jan 15, 2014 9:30:03 AM

The ability to grow intestinal stem cells creates the possibility of personalized treatments for intestinal disease.

Researchers at MIT and Brigham and Women’s Hospital have developed a method of growing unlimited quantities of intestinal stem cells thus enabling them to better understand intestinal diseases and advance the development of more personalized and effective treatment options.

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Topics: stemsaveblog, ulcerative colitis, Stemcells, autologousstemcells, intestinal tissue, small intestine, Inflammatory Bowel Disease

Migrating Stem Cells Suggest Treatment for IBD - Inflammatory Bowel Disease

Posted by Kelsey StemSave on Oct 18, 2012 6:00:01 AM

 

 

 

 

 

 

 

 

Inflammatory Bowel Disease (IBD) is a group of inflammatory conditions of the colon and small intestine. The major types of IDB are Crohn’s Disease and ulcerative colitis. In the US, approximately 1 million people suffer from diseases that fall under the category of IBD. Treatments for this disease ordinarily include steroids and immune-suppressors. However, researchers at Wake Forest have recently discovered a population of stem cells that may be able to treat IBD without the use of either steroids or immune-suppressors.

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Topics: stemsaveblog, ulcerative colitis, Stemcells, Crohn's Disease, intestinal tissue, small intestine, Inflammatory Bowel Disease

NY Times: Growing Spare Parts Inside the Body

Posted by devin@stemsave.com on Oct 4, 2012 12:38:56 AM

A recent story in the New York Times tells the story of a young infant who was born three months premature with a disorder that causes their intestinal tissue to die. The condition can be fatal and for surviving infants, current treatments are limited and invasive. Dr. Grikscheit, a pediatric surgeon at the Children’s Hospital Los Angeles, is developing methods to grow intestinal tissue ‘in vivo’ [inside the body] to replace defective intestinal tissue and provide an opportunity for children afflicted with the condition to live a normal life. “We have a huge problem that if we solve it, it will change the future for a lot of children,” she said.

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Topics: Pre-mature, stemsaveblog, Stemcells, autologousstemcells, intestinal tissue

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AAOMS - American Association of Oral and Maxillofacial Surgeons

 

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