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Under Pressure – Stem Cell Differentiation Triggered by Mechanical Force.

Posted by pamela@stemsave.com on Apr 2, 2015 11:12:16 AM

Bioengineers from the University of California, San Diego, have identified a mechanism by which stem cell differentiation is regulated by the exertion of mechanical pressure.  Using optical tweezers to apply mechanical force to stem cells, the researchers, led by Dr. Yingxiao Wang, observed the release of calcium ions, which are critical in the cellular communication required for stem cell differentiation.  Dr. Wang’s team concluded that the forces of a stem cell’s environment, such as the tension inside the jaw, can promote the cell’s maturation into stiff tissue like bone or cartilage.

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Topics: Bone loss, stemsaveblog, Bone, repair cartilage, bone regeneration, stem cell differentiation, University of California San Diego, mechanical pressure,, pressure, calcium,

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AAOMS - American Association of Oral and Maxillofacial Surgeons

 

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