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Fighting Huntington's with Stem Cell Deliveries

Posted by pamela@stemsave.com on Apr 18, 2016 1:17:00 PM

Huntington's disease is a fatal neurodegenerative disease affecting the neuronal striatum and thus motor and behavioral control. Brain-derived neurotrophic factor (BDNF) is an exciting avenue of research for Huntington’s because it has been shown to prevent neuronal death and stimulate the growth of brain cells. Additionally, Huntington’s post mortem brains indicate low concentrations of BDNF. For the first time, scientists have engineered mesenchymal stem cells(MSCs) as delivery agents for BDNF.

The UC Davis team isolated MSCs and engineered them to secrete elevated amounts of BDNF. The stem cells were then injected into immunosuppressed animal models, who were monitored for behavioral differences. The group treated with MSCs demonstrated less degeneration in the striatum, increased neuron growth activity, and an extended lifespan of 15 percent.

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Topics: neurons, Huntington's disease, brain cells, Neurodegenerative disease, mesenchymal stem cells

Parkinson’s Disease Controlled by Stem Cells

Posted by anna@stemsave.com on Feb 23, 2016 1:38:00 PM

Parkinson’s disease is a progressive, degenerative disorder of the nervous system that affects more than 60,000 Americans each year. A group of researchers from Yonsei University in South Korea has discovered that the protection of nervous tissue may be facilitated by stem cells. Animals with Parkinson’s were injected with human mesenchymal stem cells. The treatment improved the animals’ cognitive behavior and suppressed alpha-synuclein, a toxic protein in the brain.  

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Topics: parkinsons disease, stemsaveblog, stem cell therapies, neurons, mesenchymal stem cells

The Nerve of Them – Scientists Chronicle Transition of Stem Cells to Nerve Cells In Vivo.

Posted by anna@stemsave.com on Apr 16, 2015 12:08:00 PM

Scientists led by Mathias Hoehn at the Max Planck Institute for Metabolic Research have devised a novel method for documenting the process by which human stem cells transplanted into the cerebral cortex of an animal model develop into mature nerve cells.  The researchers inserted optical image reporters into the cells to emit different shades of light when certain genes were activated. By observing the sequence in which the light was emitted, the group determined the timeline of the stem cell’s transformation in vivo.

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Topics: parkinsons disease, neural stem cells, stemsaveblog, Brain, bank your stem cells, stroke recovery, nerve damage, neurons, Neurodegenerative disease

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