Sepsis is a systemic inflammatory response to severe infection, impairing metabolic function across all organ systems--affecting some 28 million people and claiming 8 million victims worldwide each year. Septic shock can lead to permanent neurological and muscular damage. Researchers at the Ottawa Hospital hope to change these statistics with an innovative therapy using injections of mesenchymal stem cells.
Scientists at the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh have succeeded in growing new liver cells in animal models by infusing Hepatic Progenitor stem cells that can develop into new liver cells. This is the first time liver function has been restored in a living subject, suggesting stem cell infusion as a possible alternative to liver transplant.