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Kidney Disease and Stem Cells

Posted by taylor@stemsave.com on May 30, 2019 2:47:00 PM

Researchers at Leiden University are using 3D printed kidneys to understand the complexities and causes of  differing forms of kidney disease affecting over 850 million individuals worldwide. One of the greatest challenges of kidney disease is that it often goes untreated due to a lack of initially observable symptoms. The researchers are utilizing the printed kidney tissue, complete with blood vessels and filtering systems of actual kidneys, to model and understand kidney disease, as well as test possible treatments prior to clinical trials. The ability to study organ pathology outside the body will enable researchers to perform extensive testing to understand the root causes of a disease from a cellular level.The ability to test treatments on living kidney tissue prior to clinical trials will limit adverse effects and expedite the approval of more effective treatments.

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Topics: stem cell organs

Vascularizing 3D Printed Organs

Posted by anna@stemsave.com on May 24, 2019 11:25:00 AM

Researchers are working to improve 3D printing by overcoming hurdles that decrease printing efficiency, particularly with larger structures. A joint effort of several universities yielded a technique that improves the vascularization (formation of blood vessels) in printed tissues by utilizing food dye. The technique allows researchers to label and track where the blood vessels and other functional structures would be located in the organs, improving the survival of the printed structures thereby overcoming a major hurdle [survival] of 3D tissue printing. This is particularly important in organs like lungs, where different, overlapping vessels are required for the transport of blood and oxygen, with the dye helping to distinguish between them.

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Topics: stem cell organs, stem cell 3D printing, 3D printed organs

Gelling with Stem Cells

Posted by maxi@stemsave.com on May 20, 2019 11:12:00 AM

Researchers at the Wake Forest Institute have developed a gel that more precisely delivers therapeutic stem cell factors. A significant hurdle to successful stem cell therapies is the failure of stem cell injections to remain localized to the affected area. To address this problem, researchers designed a gel to be delivered  to the affected area of the body to retain the therapeutic factors locally in order to maximize the efficacy of the treatments and provide a longer term solution.

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Topics: stem cell therapies, stem cell gel

Stem Cell Traumatic Brain Injury Treatment in Clinical Trials

Posted by barb@stemsave.com on May 14, 2019 12:24:00 PM

 

Researchers are using mesenchymal stem cells [MSCs] in a clinical trial to treat the loss of function that nearly always results from traumatic brain injuries (TBIs). The trial focused on patients in the U.S. and Japan, who have traumatic brain injuries in the chronic stages. The researcher’s decision to use MSCs was predicated on their differentiation capabilities as well as their inherent anti-inflammatory properties. The MSCs in the trials are cultured to clinically significant numbers then implanted back into the affected areas of the brain, where they work to to restore damaged neurons in the brain, help regenerate blood vessels and reduce the inflammation that often occurs at the injury site.

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Topics: traumatic brain injury treatment

One Step Closer to Treating Diabetes with Stem Cells

Posted by hunter@stemsave.com on May 8, 2019 11:19:00 AM

Researchers at the Harvard University’s Stem Cell Institute have engineered stem cells to become insulin producing cells, potentially providing an important source of pancreatic cells for the development of more effective treatment alternatives for millions of diabetics around the world. The technique increased insulin-producing cell yield from 30% to 80% by targeting the production of a specific protein utilized by insulin-producing beta cells. This enabled the researchers to concentrate the stem cells and yield more beta cells that can then be transplanted into diabetic individuals. Additionally, the concentration of cells should allow researchers to use smaller and less invasive devices to deliver the therapeutic cells in clinically relevant numbers.

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Topics: insulin secreting cells, treating diabetes, stem cell diabetes treatment

Stem Cells Origami Organs

Posted by davids@stemsave.com on May 3, 2019 1:30:00 PM

The American Chemical Society (ACS) has published a study that uses 3D printing to create organ frames that can be populated with cells to resemble fully fledged organs. The researchers used a structural sugar called cellulose that plants, archaea and some bacteria use for structural support in their cells. This structural component is also used in making paper, and it is therefore easy to store for prolonged periods of time and inexpensive to produce. Additionally, since cellulose structures are easy to manipulate, the researchers were able to create channels resembling blood vessels, which they then populated with human epithelial cells that typically line blood vessels.

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Topics: stem cell organs, stem cell 3D printing, 3D printed organs

Stem Cell Therapy to Revive Damaged Livers Enters Phase II Clinical Trials

Posted by maxi@stemsave.com on Apr 29, 2019 10:45:00 AM

The Belgian biotechnology company Promethera has been successfully administering a mesenchymal stem cell [MSC] therapy to treat severe liver disease - Acute-on-Chronic Liver Failure [ACLF], which was previously only treated with organ transplants. The treatment called HepaStem utilizes mesenchymal stem cells cultured from livers which, when delivered to the patient intravenously, release support and anti-inflammatory factors for existing liver cells. The company, after conducting Phase I studies to determine the safety of the treatment, is conducting Phase II clinical trials to identify optimal dosage parameters and measure treatment efficacy. 

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Topics: stem cell therapy, stem cell treatment, liver regeneration

3D Printers Mend Broken Hearts

Posted by hunter@stemsave.com on Apr 22, 2019 4:18:00 PM

Researchers in Tel Aviv have printed the first vascularized heart made from human stem cells. For the first time, researchers successfully printed heart tissue along with the blood vessels necessary for the heart to be operational. In a miniaturized version, the researchers also incorporated the chambers of the heart. The next step is scaling up the size of the printed heart to the size typically found in humans.  Researchers believe a successful scaling up of the process would accelerate parallel efforts to bio-engineer organs in vitro and ameliorate the vast organ shortage, particularly with hearts.

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Topics: dental stem cells, stem cell banking, stem cell 3D printing, stem cell printing

"Welding" Chronic Wounds with Stem Cells

Posted by anna@stemsave.com on Apr 16, 2019 2:53:00 PM

Researchers at the University of Bristol, led by Dr. Adam Perriman, have hypothesized that using stem cells that are “welded together” may be the key to healing chronic wounds that often result from diabetes and other afflictions. The research involves using mesenchymal stem cells (the same type of stem cells found in teeth) and modifying their membranes so that the cells adhere to one another.

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Topics: stem cell skin graft, stem cell grafts

3D Printing Tissues with Stem Cells

Posted by maxi@stemsave.com on Apr 10, 2019 11:47:00 AM

Researchers at UC Berkeley have been working on improving and scaling up and the printing of biomaterials with stem cells. They have developed a unique approach to ‘3D’ bioprinting by incorporating flash freezing into their process. They have improved on current techniques by printing layers of flat tissues [2D] and freezing them until they can be combined into a 3D structure. This technique was developed to overcome one of the major hurdles in scaling up 3D printing: the survival of the printed cells during the lengthy process of printing complex structures. By using 2D layers and flash freezing them before bringing them together to form a 3D organ or tissue structure, the new technique assures the survival of the cells throughout bigger, and more complex organs.

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Topics: dental stem cells, stem cell banking, stem cell printing, 3D printed organs, stem cell grafts

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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