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StemSave Blog

Curing HIV with Stem Cells

Posted by barb@stemsave.com on Feb 26, 2019 10:35:00 AM

A second patient has been cured of HIV following a stem cell transplant. It is estimated that nearly 40 million individuals are presently living with HIV around the world. Currently, the standard of care involves treating patients with anti-retroviral drugs, which keep the virus from spreading to healthy cells in the body. However, there have now been two case studies where patients received a stem cell transplant that completely eradicated the virus from the body. The stem cells came from donors with a mutation in the gene that the HIV virus normally uses to gain access to the body’s immune cells and destroy them. The mutation prevented the virus from penetrating the newly transplanted stem cells thus enabling the patients to re-established a healthy immune system.

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Topics: HIV, stem cell HIV treatment, curing HIV, AIDS

Why Dentists are Banking on Stem Cells

Posted by devin@stemsave.com on Feb 18, 2019 2:24:00 PM

Advances in dental pulp stem cell [DPSC] research and treatment are making it more pertinent than ever to participate in stem cell banking. Dentistry Today writes, “Most of the body’s stem cells are difficult to extract, found in fewer numbers, buried deep in tissues adjacent to similar-looking surrounding cells. But stem cells found in teeth are numerous and readily extracted. What’s more, dental stem cells appear to be among the fastest replicating stem cells discovered to date.”

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Topics: stem cells from teeth, dentistry, dental pulp stem cells

Osteoarthritis Treatment Gets a Nano Boost

Posted by maxi@stemsave.com on Feb 12, 2019 12:38:00 PM

Researchers at Texas A&M University have created nanoparticles that could ameliorate and prolong the effects of stem cells on cartilage regeneration in osteoarthritis. Osteoarthritis is an affliction that results from the degradation of the cartilage between joints, which serves to lubricate and prevent friction between bones. Symptoms often include joint swelling and pain, and decreased range of motion, which causes the areas around the joints to well and solidify. A treatment for osteoarthritis is vital since aging populations show an increasing prevalence of the affliction, and a stem cell treatment could contribute to longer healthspans.

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Topics: osteoarthritis, autologous stem cells, arthritis treatment, stem cell treatment

Mending Broken Hearts with Stem Cells

Posted by taylor@stemsave.com on Feb 8, 2019 1:34:00 PM

Researchers at Imperial College London have created a stem cell patch that pulses like normal heart muscle and is used to make repairs following heart attacks. Heart attacks occur when a blockage due to a clot in a blood vessel restricts blood flow to the heart, and this causes damage to the cardiac muscle, since it is without oxygen for a prolonged period of time. These patches are revolutionary in that they can pulse and contract as heart muscle constantly does. The patch is said to not only support damaged muscles but also help the heart pump more efficiently. This is essential since the muscle damage that occurs as a result of heart attacks often leads to heart failure.

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Topics: Heart Attack, regenerative treatments, heart repair, stem cell graft, cardiac muscle repair

Dental Stem Cells Used in Parkinson’s Treatment

Posted by davids@stemsave.com on Feb 4, 2019 11:08:00 AM

Researchers are utilizing vesicles secreted from dental stem cells to treat Parkinson’s Disease (PD). The study utilized these vesicles secreted by stem cells, as they are small and can easily cross the blood-brain barrier to deliver a treatment to the parts of the brain affected by PD. Parkinson’s is a neuro-degenerative disorder that affects the part of the brain that produces a neurotransmitter called dopamine, with symptoms expressing themselves as tremors and limb rigidity, among others. This study demonstrated, in an animal model, that intranasal administration of dental stem cell vesicles had a therapeutic effect by regulating the expression of proteins and preventing dopaminergic neuron death. The results showed a decrease in PD tremors and showed no adverse neurological effects over the progression of the study.

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Topics: parkinsons disease, dental stem cells, mesenchymal stem cells, regenerative medicine, autologous stem cells, stem cell treatment

Curing Type I Diabetes with Stem Cells

Posted by hunter@stemsave.com on Jan 29, 2019 3:43:00 PM

Researchers at University of California San Francisco (UCSF) have created insulin producing cells in vitro that successfully produced insulin in vivo for Type I Diabetes patients. Type I diabetics experience an autoimmune disorder which attacks and destroys the body’s insulin-producing beta cells. These patients have to take continuous insulin injections and closely and constantly monitor their blood sugar levels, since extremely high or low blood sugar levels cause diabetic ketoacidosis or hyperglycemic shock, leading to coma and death. Though diabetes is currently manageable, patients must be constantly vigilant since their bodies’ inability to regulate blood sugar often leads to other systemic diseases such as blood vessel damage, neuropathy and nephropathy, just to name a few. The study from USCF involved directing human pancreatic stem cells to become insulin-producing islets cells in the lab. In an animal model, the cells were then implanted back into the body and were shown to produce insulin in response to blood sugar spikes. Additionally, the islets produced other essential hormones for blood sugar regulation, fully resembling normal pancreatic islets.


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Topics: Diabetes, Type-1 Diabetes, autoimmune disease, treating diabetes, stem cell treatment

Alzheimer’s Treated With Stem Cells

Posted by anna@stemsave.com on Jan 21, 2019 10:19:00 AM

In a Phase II clinical trial, researchers are using autologous (the patients’ own) mesenchymal stem cells to treat Alzheimer’s disease. According to the Centers for Disease Control (CDC) 5.7 million Americans are currently suffering from Alzheimer’s [with approximately 5.5 million over the age of 65 and approximately 220k under 65 experiencing early onset Alzheimer’s] with the number expected to triple by 2060. Additionally, the disease is one of the top 10 leading causes of death in U.S. adults; and while incidents of other common ailments like heart disease and cancer are decreasing, Alzheimer’s is on the rise.

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Topics: Alzheimer's disease, Phase I/II clinical trial, treating Alzheimer's, mesenchymal stem cells, autologous stem cells, stem cell treatment

Autism Treated With Stem Cells

Posted by barb@stemsave.com on Jan 14, 2019 2:58:00 PM

Researchers at Duke University have utilized autologous (the patient’s own) stem cell infusions to promote increased connectivity in the brain that allowed for improved communication and language abilities in children with Autism Spectrum Disorder (ASD). The stem cells used in the trial were the patients’ own cord blood stem cells, which were banked at birth and played a key role in alleviating the symptoms of ASD in these patients. The Phase I Clinical Trial utilized the autologous stem cells in i.v. infusions that were meant to deliver the cells to the white matter, which is one of the brain tissues that differs developmentally between individuals with and without ASD. Additionally, the study targeted the neuroinflammation present in individuals with ASD.

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Topics: autism and stem cells, autologous stem cells, Autism Spectrum Disorder, stem cell treatment

Repairing Permanent Corneal Damage with Stem Cells

Posted by pamela@stemsave.com on Jan 8, 2019 1:20:00 PM

Researchers at Stanford University and the University of Illinois at Chicago are utilizing factors secreted from stem cells to repair severe corneal damage and scarring, which causes severe side effects, including blindness. This study utilizes a novel approach that delivers the treatment directly to the site of the injury compared to conventional treatments. Typically, corneal damage is treated with lubricating drops, steroids and patching the injury site, but this novel treatment approach seeks to treat the symptoms of the injury and repair the scar tissue completely. The treatment involves using repair factors secreted by mesenchymal stem cells, along with a biological gel made of hyaluronic acid and chondroitin sulfate which promote the regeneration of the cornea membrane.

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Topics: corneal disease, Blindness, mesenchymal stem cells, corneal damage, corneal injury

Lifesaving Platelets Created with Stem Cells

Posted by maxi@stemsave.com on Jan 3, 2019 3:32:00 PM

Researchers at Keio University in Tokyo have developed a method to generate platelets negating the need to obtain them from donated blood. Typically, platelets come from blood donations and have an extremely short shelf-life of 5 days. Platelets are vital to a great number and variety of medical procedures as they are responsible for clotting and can prevent patients from bleeding out from serious injuries or during surgeries. Additionally, platelets are difficult to match from donor to patient and donated platelets run the risk of rejection by the recipient. Creating a patient’s own platelets from their own stem cells would negate the need for a donor and virtually eliminate any possibility of rejection. Generating patient specific platelets would also alleviate the shortages that are typical of the current platelet recovery environment.

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Topics: blood cells, mesenchymal stem cells, platelets, stem cell use

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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