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Alzheimer’s Treated With Stem Cells

Posted by anna@stemsave.com on Jan 21, 2019 10:19:00 AM

In a Phase II clinical trial, researchers are using autologous (the patients’ own) mesenchymal stem cells to treat Alzheimer’s disease. According to the Centers for Disease Control (CDC) 5.7 million Americans are currently suffering from Alzheimer’s [with approximately 5.5 million over the age of 65 and approximately 220k under 65 experiencing early onset Alzheimer’s] with the number expected to triple by 2060. Additionally, the disease is one of the top 10 leading causes of death in U.S. adults; and while incidents of other common ailments like heart disease and cancer are decreasing, Alzheimer’s is on the rise.

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Topics: treating Alzheimer's, Alzheimer's disease, stem cell treatment, autologous stem cells, mesenchymal stem cells, Phase I/II clinical trial

Autism Treated With Stem Cells

Posted by barb@stemsave.com on Jan 14, 2019 2:58:00 PM

Researchers at Duke University have utilized autologous (the patient’s own) stem cell infusions to promote increased connectivity in the brain that allowed for improved communication and language abilities in children with Autism Spectrum Disorder (ASD). The stem cells used in the trial were the patients’ own cord blood stem cells, which were banked at birth and played a key role in alleviating the symptoms of ASD in these patients. The Phase I Clinical Trial utilized the autologous stem cells in i.v. infusions that were meant to deliver the cells to the white matter, which is one of the brain tissues that differs developmentally between individuals with and without ASD. Additionally, the study targeted the neuroinflammation present in individuals with ASD.

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Topics: Autism Spectrum Disorder, autism and stem cells, autologous stem cells, stem cell treatment

Repairing Permanent Corneal Damage with Stem Cells

Posted by pamela@stemsave.com on Jan 8, 2019 1:20:00 PM

Researchers at Stanford University and the University of Illinois at Chicago are utilizing factors secreted from stem cells to repair severe corneal damage and scarring, which causes severe side effects, including blindness. This study utilizes a novel approach that delivers the treatment directly to the site of the injury compared to conventional treatments. Typically, corneal damage is treated with lubricating drops, steroids and patching the injury site, but this novel treatment approach seeks to treat the symptoms of the injury and repair the scar tissue completely. The treatment involves using repair factors secreted by mesenchymal stem cells, along with a biological gel made of hyaluronic acid and chondroitin sulfate which promote the regeneration of the cornea membrane.

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Topics: corneal damage, Blindness, corneal disease, corneal injury, mesenchymal stem cells

Lifesaving Platelets Created with Stem Cells

Posted by maxi@stemsave.com on Jan 3, 2019 3:32:00 PM

Researchers at Keio University in Tokyo have developed a method to generate platelets negating the need to obtain them from donated blood. Typically, platelets come from blood donations and have an extremely short shelf-life of 5 days. Platelets are vital to a great number and variety of medical procedures as they are responsible for clotting and can prevent patients from bleeding out from serious injuries or during surgeries. Additionally, platelets are difficult to match from donor to patient and donated platelets run the risk of rejection by the recipient. Creating a patient’s own platelets from their own stem cells would negate the need for a donor and virtually eliminate any possibility of rejection. Generating patient specific platelets would also alleviate the shortages that are typical of the current platelet recovery environment.

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Topics: platelets, blood cells, stem cell use, mesenchymal stem cells

Stem Cells Shed Light on Autism Spectrum Disorder

Posted by devin@stemsave.com on Dec 29, 2018 1:51:00 PM

Researchers at the Salk Institute have used stem cells to understand the changes in neural development for individuals with Autism Spectrum Disorder (ASD). This study has uncovered the first measurable changes in neuronal development of individuals with ASD, which is a major step toward understanding the disorder and ameliorating current therapies. The research found that by allowing the stem cells to differentiate into neurons, several developmental steps differed in cells from individuals with ASD compared to the control group. This led researchers to the conclusion that changes occur much earlier in neuronal development, since cells from individuals with ASD turn on their genes for neuronal development much earlier and the neurons grew faster compared to controls.

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Topics: Autism Spectrum Disorder, autism and stem cells, stem cell research, stem cell therapy

Advancing Prosthetics with Stem Cells

Posted by barb@stemsave.com on Dec 23, 2018 4:03:00 PM

Researchers at University of Minnesota are seeking to improve the functionality of prosthetics by introducing human tissue  into the technology thereby creating ‘bionic prosthetics.’ Engineer Michael McAlpine has taken advantage of the regenerative properties  stem cells and advances in 3D printing to create bionic prosthetics that are able to send and receive signals and impulses that more closely mimic natural body parts. Utilizing the technique, McAlpine has created a bionic ear that can detect and perceive sound, as well as a retina that has photodetectors translate light into electrical signals. Combining prosthetics, 3D printing and stem cells to more closely replicate the appearance and functionality of human tissues and body parts should significantly improve the quality of life of patients who currently have conventional prosthetics that do not resemble the form nor function of the lost limb.

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DoD Growing Bones With Stem Cells to Treat Wounded Soldiers

Posted by hunter@stemsave.com on Dec 17, 2018 11:17:00 AM

The U.S. Department of Defense [DOD] has approved a grant of $2 million to the University of Arizona [UA] to advance the development of their technology combining 3D printing and stem cell grafting to create a better alternative to conventional bone replacement. Current standard of care for shattered bones involves using cadaver bones and support rods to replace bones entirely. However, these treatments are often ephemeral since the cadaver bone is dead and becomes increasingly fragile over time. The technique being developed by UA utilizes advanced 3D printing to create a scaffold that mimics the structure of bone and then seeds it with the patient’s own stem cells, along with calcium, to grow a bone that will be sturdier. Since the technique will use the patient’s own stem cells, it virtually eliminates the possibility of rejection. 

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Topics: stem cell graft, bone grafting, bone trauma

Parkinson’s Disease Resistant Stem Cells

Posted by taylor@stemsave.com on Dec 12, 2018 2:57:00 PM

Researchers at the University of Edinburgh have made a major breakthrough in the development of a treatment for Parkinson’s disease. Clinical trials are currently underway that utilize stem cells to treat Parkinson’s by injecting healthy stem cells directly into the brain. However, there is one major hurdle: the healthy injected cells can become diseased from the nearby cells exhibiting Parkinson’s symptoms. In lab tests, the researchers used CRISPR to splice the DNA of the stem cells to eradicate the gene that causes the toxic clumps of cells in the brain, which contribute to the neuronal degeneration. The edited stem cells also successfully produced dopamine, which is significantly lacking in Parkinson’s patients.

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Topics: Parkinson's, parkinsons research, stem cell injection, regenerative medicine

ALS Phase III Clinical Trial with Autologous Stem Cells

Posted by pamela@stemsave.com on Dec 7, 2018 12:36:00 PM

Phase III Clinical Trials to treat ALS were announced by Brainstorm Therapeutics utilizing their successful NurOwn stem cell technology to treat amyotrophic lateral sclerosis (ALS). The company has received a $16 million grant from the California Institute for Regenerative Medicine [CIRM] to conduct the trial. The technology utilizes the patient’s own mesenchymal stem cells, which are differentiated to secrete neurotrophic factors that support the damaged neurons and aid the survival of other neurons. The stem cells are then injected directly into the muscle or spinal canal in order to deliver the cells directly to the areas most affected by ALS.

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Fighting Epilepsy With Stem Cells

Posted by anna@stemsave.com on Nov 29, 2018 12:10:00 PM

Researchers at Texas A&M University are utilizing stem cell injections into the brain to alleviate the most common and severe case of seizures of Temporal Lobe Epilepsy (TLE) in an animal model. The experimental treatment resulted in 70% of the subjects experiencing a reduction in the number of seizures with researchers expecting the number to climb as the research advances. Current treatment of TLE involves treatment with medication [to which 40% of patients do not respond] or, invasive surgery. To eliminate this type of epilepsy, some patients have their entire hippocampus removed, which can lead to disastrous side effects impacting the patient’s mood and memory.  

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Topics: epilepsy, epileptic seizures, stem cell treatment, autologous stem cells

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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