Dr. Valery Krizhanovsky at the Weizmann Institute of Science has built on the work of previous researchers in order to identify the role of senescent cells in age-related ailments, such as cancers, atherosclerosis, Alzheimer’s Disease, Parkinson’s and others. He explains that senescent cells accumulate in the body, do not follow the stable cell cycle and cease to divide. However, despite the body’s mechanisms for apoptosis, or programmed cell death, these aged cells do not self-destruct. Using stem cells to grow human tissue in the lab, Krizhanovsky is able to accurately determine the behavior of senescent cells in humans, rather than making observations solely based on animal subjects.
“Altogether, these studies focus on elimination of senescent cells as a promising strategy for extension of health span and lifespan as well as directed treatment of age-related diseases and to uncover the molecular mechanisms of the effect of senescent cells on these conditions.”
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