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barb@stemsave.com

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Curing HIV with Stem Cells

Posted by barb@stemsave.com on Feb 26, 2019 10:35:00 AM

A second patient has been cured of HIV following a stem cell transplant. It is estimated that nearly 40 million individuals are presently living with HIV around the world. Currently, the standard of care involves treating patients with anti-retroviral drugs, which keep the virus from spreading to healthy cells in the body. However, there have now been two case studies where patients received a stem cell transplant that completely eradicated the virus from the body. The stem cells came from donors with a mutation in the gene that the HIV virus normally uses to gain access to the body’s immune cells and destroy them. The mutation prevented the virus from penetrating the newly transplanted stem cells thus enabling the patients to re-established a healthy immune system.

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Topics: HIV, stem cell HIV treatment, curing HIV, AIDS

Autism Treated With Stem Cells

Posted by barb@stemsave.com on Jan 14, 2019 2:58:00 PM

Researchers at Duke University have utilized autologous (the patient’s own) stem cell infusions to promote increased connectivity in the brain that allowed for improved communication and language abilities in children with Autism Spectrum Disorder (ASD). The stem cells used in the trial were the patients’ own cord blood stem cells, which were banked at birth and played a key role in alleviating the symptoms of ASD in these patients. The Phase I Clinical Trial utilized the autologous stem cells in i.v. infusions that were meant to deliver the cells to the white matter, which is one of the brain tissues that differs developmentally between individuals with and without ASD. Additionally, the study targeted the neuroinflammation present in individuals with ASD.

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Topics: autism and stem cells, autologous stem cells, Autism Spectrum Disorder, stem cell treatment

Advancing Prosthetics with Stem Cells

Posted by barb@stemsave.com on Dec 23, 2018 4:03:00 PM

Researchers at University of Minnesota are seeking to improve the functionality of prosthetics by introducing human tissue  into the technology thereby creating ‘bionic prosthetics.’ Engineer Michael McAlpine has taken advantage of the regenerative properties  stem cells and advances in 3D printing to create bionic prosthetics that are able to send and receive signals and impulses that more closely mimic natural body parts. Utilizing the technique, McAlpine has created a bionic ear that can detect and perceive sound, as well as a retina that has photodetectors translate light into electrical signals. Combining prosthetics, 3D printing and stem cells to more closely replicate the appearance and functionality of human tissues and body parts should significantly improve the quality of life of patients who currently have conventional prosthetics that do not resemble the form nor function of the lost limb.

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Stem Cells Help Patients Following Chemo/Radiation

Posted by barb@stemsave.com on Sep 28, 2018 11:41:00 AM

Researchers are utilizing mesenchymal stem cell (MSC) infusions to help heal severe tissue damage following radiation treatments. Often, when patients receive treatment for cancer, the process involves painful and prolonged side effects from the chemotherapy and radiation, which significantly impacts the patients’ quality of life, even when in remission. MSC intravenous infusions demonstrated both healing properties and resulted in a reduction of pain and fistulization (the abnormal connections between organs due to injury and inflammation) following radiation. The patients receiving the treatment had sustained intestinal tissue damage following radiation treatments, and prior to the treatment all patients were experiencing pain, inflammation, fibrosis and hemorrhaging.

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Topics: stem cell therapy, mesenchymal stem cells, cancer treatment, radiation treatments

Stem Cells Used to Understand ALS and Alzheimer’s

Posted by barb@stemsave.com on Jul 30, 2018 12:42:00 PM

A City of Hope researchers are utilizing stem cells to understand the genetic mutations that occur in astrocytes, a type of neuron, as well as damage to the myelin sheath, which is integral to the development of ALS and Alzheimer’s. Stem cells were used to create a model of Alexander disease, which is a neurological disorder similar to ALS and Alzheimer’s in its pathology, part of which involves a genetic mutation that hinders the production of an adequate myelin sheath, a fatty membrane that covers neurons and expedites signal transduction. Using this technique, the researchers homed in on the CHI3L protein, which seems to be primarily responsible for neuroinflammation and stunted neuronal development, including an inadequate myelin sheath.

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Topics: Alzheimer's disease, regenerative treatments

Stem Cells Bone Up

Posted by barb@stemsave.com on Jun 28, 2018 2:45:00 PM

Bone grafts help millions of people suffering from bone loss due to trauma or disease. Typically, traumatic bone injuries and bone loss due to disease have been mended with synthetic grafts or segments of bone taken from another area in the patient’s body. However, these treatments do not last long-term in growing bodies, and lack vasculature required for mature bone growth. In vitro tests at the New York Stem Cell Foundation Research Institute of a new technology called Segmental Additive Tissue Engineering (SATE) have demonstrated stem cell grown segments of bone creating large scale, personalized grafts. The SATE protocol seeds the patient’s own stem cells into a scaffold and directs the cells to develop into customized and vascularized bone segments, which pose virtually no risk of rejection, and are able to grow with the patient.

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Topics: bone repair, bone regrowth, bone regeneration, stem cell graft

Printing Corneas with Stem Cells

Posted by barb@stemsave.com on May 23, 2018 5:05:00 PM

Researchers at Newcastle University are 3D printing corneas utilizing stem cells. The process involves mixing stem cells in a bio-gel which is derived from seaweed and collagen that allows these stem cells to be cultured and printed easily and efficiently into fully functioning corneas. The cornea plays an important role in focusing light that enters the eye. Technically, blindness caused by corneal damage is easily reversible with a corneal transplant. However, there is a vast shortage of donor corneas due to general organ and tissue donation shortages.  In addition, there is also a significant  risk of rejection - as is the case with any donated tissue.

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Topics: 3D Printing, corneal transplant, stem cell 3D printing

Curing Beta Thalassemia With Stem Cells and CRISPR

Posted by barb@stemsave.com on Apr 10, 2018 9:00:00 AM

A Phase I clinical trial to test the efficacy of genetically modified autologous (the patient’s own) stem cells to treat beta-thalassemia has been initiated. This condition is an inherited disease that affects the production of hemoglobin, which is responsible for carrying oxygen in the body and delivering it to tissues and vital organs. With thousands of new cases every year, this condition often results in fatigue, bone fragility and extreme anemia (a deficiency of iron in the blood). This trial aims to create a groundbreaking protocol that would obtain autologous stem cells from the patients, genetically alter them to produce the missing protein responsible for the condition and, reintroduce the stem cells back into the body through a transfusion.

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Topics: Beta-thalassemia, stem cell therapy, Genetic Diseases, genetic engineering

Stem Cells Could Be the Answer to Infertility

Posted by barb@stemsave.com on Apr 1, 2018 3:30:00 PM

In a clinical trial conducted at Augusta University Medical College of Georgia, doctors have found that autologous [the patients’ own] stem cell injections can restore estrogen levels in the ovaries, the lack of which contributes to Premature Ovarian Failure (POF). Patients who received the injections saw an increase in estrogen levels in 3 months following the injections and, in 6 months, resumed regular menstruation cycles, which had ceased due to premature menopause. POF primarily affects women under 40 and causes the ovaries to cease their normal functions, leading to premature menopause, and rendering the women incapable of conceiving a child. The procedure involves the  collection of the patients’ own stem cells, which are then  isolated and re-introduced into the body to rejuvenate the prematurely aged ovaries. The study uses a minimally invasive treatment to inject the stem cells into one ovary, leaving the other untreated as a control. Through ultrasound imaging, the treated ovary has increased in size compared to the control, signifying a restoration in normal ovarian function.

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Autism Spectrum Disorder Ameliorated with a Patient’s Own Stem Cells

Posted by barb@stemsave.com on Feb 15, 2018 5:39:03 PM

Families choosing to bank their stem cells – usually in the form of cord blood and/or dental pulp stem cells, typically view their decision as “biological insurance.” A Phase II clinical trial is investigating the safety and efficacy of autologous [the patient’s own] cord blood stem cells to treat children with behavioral and social difficulties associated with Autism Spectrum Disorder (ASD). In a clear demonstration of the value of banking your own stem cells, only families that chose to bank their children’s cord blood were qualified to participate in the study. 

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Topics: autism and stem cells, dental stem cell banking, Umbilical cord blood, regenerative medicine, Autism Spectrum Disorder, stem cell banking

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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