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Recruiting Stem Cells to Combat Gum and Bone Loss Due to Periodontal Disease

Posted by devin@stemsave.com on Mar 15, 2019 3:10:00 PM

Researchers at the American Chemical Society (ACS) have developed a biopolymer that would be implanted into an affected gum line to recruit stem cells and restore the damage caused by periodontal disease. With the Centers for Disease Control predicting that nearly half of all Americans will be affected by periodontal disease during their lifetimes,  the new regenerative treatment technique would save healthy teeth, avoid prolonged and costly treatments and provide dentists with a more effective and less invasive treatment option for their patients.

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Topics: dental stem cells, bone regeneration, stem cell rejuvenation, periodontal disease

Why Dentists are Banking on Stem Cells

Posted by devin@stemsave.com on Feb 18, 2019 2:24:00 PM

Advances in dental pulp stem cell [DPSC] research and treatment are making it more pertinent than ever to participate in stem cell banking. Dentistry Today writes, “Most of the body’s stem cells are difficult to extract, found in fewer numbers, buried deep in tissues adjacent to similar-looking surrounding cells. But stem cells found in teeth are numerous and readily extracted. What’s more, dental stem cells appear to be among the fastest replicating stem cells discovered to date.”

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Topics: stem cells from teeth, dentistry, dental pulp stem cells

Stem Cells Shed Light on Autism Spectrum Disorder

Posted by devin@stemsave.com on Dec 29, 2018 1:51:00 PM

Researchers at the Salk Institute have used stem cells to understand the changes in neural development for individuals with Autism Spectrum Disorder (ASD). This study has uncovered the first measurable changes in neuronal development of individuals with ASD, which is a major step toward understanding the disorder and ameliorating current therapies. The research found that by allowing the stem cells to differentiate into neurons, several developmental steps differed in cells from individuals with ASD compared to the control group. This led researchers to the conclusion that changes occur much earlier in neuronal development, since cells from individuals with ASD turn on their genes for neuronal development much earlier and the neurons grew faster compared to controls.

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Topics: autism and stem cells, stem cell therapy, stem cell research, Autism Spectrum Disorder

MS Phase II Clinical Trial Launched Using Patient Stem Cells

Posted by devin@stemsave.com on Nov 4, 2018 9:44:00 AM

BrainStorm Cell Therapuetics is currently launching a Phase II clinical trial utilizing mesenchymal stem cells (MSCs) that are cultured to develop into neurological components able to treat progressive multiple sclerosis (MS). The proprietary technology called NurOwn uses a patient’s own (autologous) MSCs that are modified outside of the body and returned to repair and support neurons that are attacked in patients with MS. The stem cells are modified to produce growth factors, which support neurons and enhance differentiation and survival of neural cells.

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Topics: multiple sclerosis, MS, autologous stem cells, multiple sclerosis treatment, stem cell treatment

Meniscus Tears Repaired with Stem Cells

Posted by devin@stemsave.com on Jul 9, 2018 10:36:00 AM

A study cited in the Journal of Medical Cases has demonstrated successful results utilizing autologous (the patient’s own) stem cells to repair a torn meniscus without surgical intervention. Meniscal injuries are the most frequent knee injuries, and they are particularly common in athletes, but can also occur due to aging. Typically, meniscal tears are treated with surgical intervention, which requires “stitches” meant to hold the tear together until it heals, or cutting out the torn part entirely. The surgical intervention method, though safe, requires extensive physical therapy to strengthen supporting muscles, as well as weeks of recovery time on crutches. Imaging of a tear following a stem cell therapy showed that 9 months after a stem cell injection, the tear healed to the point where it was virtually unnoticeable.

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Topics: stem cell therapy, meniscus tear treatments, stem cell repair, meniscus tear repair

Young Stem Cells Rejuvenate Aged Cells

Posted by devin@stemsave.com on Mar 6, 2018 3:45:00 PM

A major obstacle to successful bone marrow transplants (BMT) is rejection due to the age discrepancy of the donor and recipient, with older donors presenting problems due to the donor stem cells’ loss of efficacy with age. The older stem cells’ compromised ability to actively regenerate (given that older stem cells are less active than younger stem cells) increases the risk of age-related rejection significantly. In a groundbreaking study, researchers have discovered that the in-vitro (outside the body) introduction of young mesenchymal stem cells (MSCs) to aged donor hematopoietic stem cells (HSCs) used for transplants resulted in the rejuvenation of the donor cells likely improving the efficacy of the transplant.

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Topics: stem cell transplant, regenerative medicine, bone marrow transplants, stem cell rejuvenation

Type 2 Diabetes Mellitus - Stem Cell Clinical Trials

Posted by devin@stemsave.com on Dec 19, 2017 4:45:00 PM

In several clinical and animal studies, researchers are utilizing mesenchymal stem cells (MSCs) to treat Type II Diabetes Mellitus (T2DM). Type 2 Diabetes affects approximately 415 million people worldwide, with diabetes mellitus (DM) further exacerbating diabetes’ adverse health effects. Symptoms of DM are caused by both a lack of insulin, as-well-as an intolerance to the scarce amount of insulin that is produced by the pancreatic islet cells. DM is typically a precursor to ischemic heart disease, stroke, blindness and chronic kidney disease with no effective treatments currently available to prevent these complications. With previous treatments using donated organs and insulin producing cells proving unsuccessful, MSCs are emerging as an extremely effective tool to restore normal function to the pancreatic islet cells and alleviate the other symptoms of DM. MSCs (the same type of stem cells that are found in teeth) not only normalize natural insulin levels, but also help ameliorate insulin resistance in the body’s tissues by creating a favorable microenvironment.

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Topics: pancreatic beta cells, type 2 diabetes, mesenchymal stem cells, diabetes mellitus, stem cell diabetes treatment, pancreatic islet cell regeneration

Stem Cells Reverse Paraplegia

Posted by devin@stemsave.com on Nov 29, 2017 4:45:00 PM

Researchers at the Technion-Israel Institute have directed stem cells to differentiate into neurons with the potential to repair spinal damage that causes paralysis in the legs, known as paraplegia. In an animal model, subjects suffering injury to their spinal cords, causing them to lose all mobility and feeling in their hind limbs, were treated with human stem cells cultured to differentiate into support factors that promote neural growth and survival. Three weeks after administering the stem cell treatment, 42% of the subjects began either walking or showing significant improvements in bearing weight on their hind legs. Furthermore, over 75% of the subjects responded to stimulation in their hind legs. When compared to the placebo group that received no stem cells, the results were impressive and demonstrate  the immense potential of utilizing stem cells to restore the neural connections in the spine following a traumatic injury.

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Topics: Paralysis, paraplegia, regenerative medicine, autologous stem cells, adult stem cells, quadriplegia, stem cell paralysis treatment

Diabetic-PAD Symptom Relief with Stem Cells

Posted by devin@stemsave.com on Nov 8, 2017 4:45:00 PM

A study at the University of Illinois found that stem cell injections can promote angiogenesis, or blood vessel generation, which improves the circulation problems associated with diabetes. The condition in question is peripheral artery disease or PAD, in which patients suffer from restricted blood flow caused by plaque on the walls of the arteries; most typically in the leg. This is due in part to poor circulation in diabetic patients which can cause moderate to severe pain during any movement of the leg. It can also lead to ulcers, sores and, in severe cases, gangrene, which can lead to amputation. In an animal model, stem cell injections were shown to improve blood flow and circulation in problematic areas. They also altered the gene expression of surrounding cells to reduce inflammation, which typically exacerbates the problem. PAD currently lacks effective treatments options and is difficult to diagnose until it has progressed severely hence, the study points to a potential breakthrough therapy that utilizes the patient’s own stem cells.

 

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Topics: diabetic wounds, PAD, stem cell treatments, regenerative medicine, autologous stem cells, diabetic treatment

Stem Cell Treatment Shows Progress in Reversing MS

Posted by devin@stemsave.com on Aug 23, 2017 4:45:00 PM

Researchers in India have used an autologous stem cell treatment in a pilot pre-clinical study to completely reverse the adverse effects of a quickly progressing case of MS (multiple sclerosis). MS is an autoimmune disorder in which the body attacks its own nervous system by breaking down the myelin sheath on neurons. Proper myelination is responsible for faster transmission of nerve signals and aggressive forms of MS cause patients to lose motor functions in their limbs, as well as experience memory and cognition problems. The patient in this study was experiencing a particularly degenerative form of MS, with multiple relapses over the years, and he began losing his ability to walk. After receiving an injection of his own mesenchymal stem cells (the same type of stem cells found in teeth), as well as a monitored diet and physical therapy, the patient experienced immediate improvement. He was soon able to walk and even run again, which he had been unable to do for over five years.

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Topics: multiple sclerosis, clinical trials, stem cell treatments, Neurodegenerative disease, mesenchymal stem cells, regenerative medicine, autologous stem cells

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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