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maxi@stemsave.com

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Lifesaving Platelets Created with Stem Cells

Posted by maxi@stemsave.com on Jan 3, 2019 3:32:00 PM

Researchers at Keio University in Tokyo have developed a method to generate platelets negating the need to obtain them from donated blood. Typically, platelets come from blood donations and have an extremely short shelf-life of 5 days. Platelets are vital to a great number and variety of medical procedures as they are responsible for clotting and can prevent patients from bleeding out from serious injuries or during surgeries. Additionally, platelets are difficult to match from donor to patient and donated platelets run the risk of rejection by the recipient. Creating a patient’s own platelets from their own stem cells would negate the need for a donor and virtually eliminate any possibility of rejection. Generating patient specific platelets would also alleviate the shortages that are typical of the current platelet recovery environment.

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Topics: platelets, blood cells, stem cell use, mesenchymal stem cells

Beefing Up with Stem Cells

Posted by maxi@stemsave.com on Nov 23, 2018 12:43:00 PM

Biotech company, Aleph Farms, has recently developed the world’s first lab-grown steak developed from stem cells. In the last few years, huge strides have been made in the development ofculturing methodologies that mayenableresearchers and farmers to grow meat without the environmental consequences of livestock farming[while also addressing the fear of consuming antibiotic-raised livestock]. Since stem cell grown burgerswerecreated nearly 5 years ago, researchers have been working diligently to improve their stem cell differentiation techniques. Culturinga steak involvesthe replicationof complex muscular structures. Hence, a lab grown steak represents a significant advancement in differentiation technology and know-how.

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Stem Cells Treat Atherosclerosis

Posted by maxi@stemsave.com on Oct 10, 2018 1:41:00 PM

Mesenchymal stem cell (MSC) injections have been successfully utilized in a pre-clinical study to treat blood vessel constriction due to atherosclerosis. Atherosclerosis is a disease that occurs when the walls of the arteries become hardened and narrow, due to the damage caused by high blood pressure, smoking and excess cholesterol. This causes further complications, since atherosclerosis is the most common cause of heart attacks, strokes and other arterial diseases. In this study, stem cells’ anti-inflammatory properties in an animal model helped decrease the accumulation of immune cells in the arteries that contribute to plaques. MSC injections have shown to decrease atherosclerotic plaques by 30-40%. 

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Baby Teeth Stem Cells Restore Damaged Permanent Teeth

Posted by maxi@stemsave.com on Aug 28, 2018 3:44:00 PM

University of Pennsylvania researchers have utilized dental stem cells from baby teeth to restore injured teeth. The clinical trial involved the use of the patient’s own (autologous) stem cells to treat an injured permanent tooth. The stem cells were obtained from a healthy baby tooth [hence, posed no risk of rejection, since they were the patient’s own], expanded in the lab and implanted into the injured tooth. In follow-ups one year following the procedure, patients in the experimental group regained sensation in the previously injured tooth. The researchers also observed a significant regeneration of dentin, which is the hard part of the tooth, as well as vascularization in the pulp, which led to healthy root development and increased circulation.

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Topics: natural tooth repair, tooth regeneration, baby tooth, stem cells from teeth, baby teeth stem cells

Stem Cell Hydrogel Heals Aging Muscles

Posted by maxi@stemsave.com on Aug 10, 2018 10:25:00 AM

Researchers at Georgia Tech are investigating the efficacy of a stem cell infused hydrogel to facilitate the healing of muscular injuries, particularly common in elderly individuals as well as muscular dystrophy patients. The stem cells found in the hydrogel are called muscle satellite cells, and younger individuals have plentiful stores of these cells to actively and efficiently repair muscle injuries as soon as they happen.  However, as individuals age, stem cells become less plentiful and less active, hence, for older individuals, recovery from muscle injuries becomes more protracted and less certain. For individuals with muscular dystrophy, muscle cells are under constant stress. The research seeks to improve on the more common approach of injecting the stem cells directly into the site of damaged muscle, by using the hydrogel to protect the stem cells and ensure that as many of them as possible reach the affected site thereby improving the efficacy of the treatment.

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Topics: muscle strengthening, muscle repair, muscle regeneration, stem cell therapy

Lupus Stem Cell Study Endorsed by National Institutes of Health (NIH)

Posted by maxi@stemsave.com on Jun 20, 2018 5:49:00 PM

A phase II clinical study investigating the efficacy of mesenchymal stem cells [MSCs] to treat moderate to severe lupus symptoms has been launched by the Lupus Foundation of America, in collaboration with the National Institute of Allergy and Infectious Diseases (part of the NIH). Lupus is a chronic autoimmune disorder in which the immune system can affect virtually any tissue in the body, including skin, joints and organs. MSCs represent a promising treatment option in that, in addition to the inherent plasticity of MSCs, they also possess immune modulation properties.  The NIH is providing resources and oversight for the study, which will investigate how mesenchymal stem cells can effectively regulate and limit the autoimmune response of Lupus sufferers.  Currently there are no effective options for their lupus symptoms other than steroid treatments, which have significant side effects, as they are detrimental to vital organ function.

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Topics: lupus, stem cell therapy, mesenchymal stem cells, regenerative treatments

Stem Cell Generated Organs

Posted by maxi@stemsave.com on Jun 9, 2018 3:47:00 PM

In a breakthrough study, 3D printed organs have been vascularized to sustain the growing tissue and bring printed organs one step closer to fruition. Currently, hundreds of thousands of Americans are on waiting lists for life-saving organs, and 20 patients die waiting each day. This innovative research by Prellis Biologics is making headway to allow for more effective and efficient printing of organs. 3D printing has had to overcome 2 major obstacles: the development of a biological scaffold to allow for three dimensional growth of cells into the desired organs, and the oxygenation and nutrient delivery to the growing tissue for prolonged periods of printing time using blood vessels. Though a biological medium for 3D tissue growth has already been developed, Prellis has created a more effective an efficient method of vascularizing the growing organ tissue, as well as expediting the printing process as a whole.

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Topics: stem cell 3D printing, printed organs, stem cell organs, regenerative treatments

Lymphoma Treatment Utilizing Stem Cells Receives FDA Approval

Posted by maxi@stemsave.com on May 4, 2018 1:08:00 PM

A genetically modified stem cell therapy for Diffuse Large B-Cell Lymphoma (DLBCL) has been approved by the FDA. Researchers at the Abramson Cancer Center, in collaboration with Novartis, have successfully administered a CAR-T Cell therapy, called Kymriah, for the most common type of non-Hodgkin Lymphoma. DLBCL is a fast growing cancer that affects B lymphocytes, which are responsible for producing antibodies that help fight infections in the body. This groundbreaking treatment involves obtaining autologous (the patient’s own) T cells, which are a more specialized type of stem cell, and genetically engineering the cells to track down and destroy cancerous cells. 

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Topics: lymphoma, cancer treatment, stem cell therapy

Growing a Kidney with Stem Cells

Posted by maxi@stemsave.com on Mar 1, 2018 3:30:00 PM

In a major breakthrough, researchers are one step closer to growing functional kidneys from human stem cells with the potential of eliminating the need for donated kidney transplants. The collaborative effort by the researchers at Murdoch Children’s Research Institute, University of Melbourne and Leiden University Medical Center has made progress in vascularizing a lab grown kidney organoid. Kidney tissue has been successfully grown in a lab - with all requisite cell types. However, vascularizing the tissue (allowing for blood flow) has proved difficult.  This breakthrough research effort has overcome this obstacle to kidney replacement.  In an animal model, researchers implanted the human stem cell-derived organoid into healthy kidney tissue,  with the organoid maturing and vascularizing into fully fledged kidney tissue in vivo in 4 weeks.

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Stem Cells Alleviate Airway Hypersensitivity in Asthma

Posted by maxi@stemsave.com on Jan 24, 2018 1:51:09 PM

asthma-s16-man-inhaler.jpg

The immunomodulatory properties of mesenchymal stem cells [MSCs] are being tested to relieve the symptoms of asthma - airway inflammation which results in difficulty breathing. Asthmatic symptoms are caused by the body’s hypersensitive immune response to inhaling harmless allergens that trigger inflammation, which constricts airways and causes breathing to become extremely difficult, requiring an inhaler to counteract the inflammation. When administered in an animal model, mesenchymal stem cells (the same type of stem cells found in teeth) have successfully produced anti-inflammatory factors and neuropeptides that counteracted airway hypersensitivity and the production of pro-inflammatory receptors.

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AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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