Researchers in Japan successfully used dental pulp stem cells [DPSCs] in animal models to stimulate peripheral neural regrowth and ameliorate neural losses associated with autologous nerve grafts, which can lead to diminished function and decreased sensation. The dental pulp stem cells demonstrated regeneration of more myelinated axons than in the control group, which received autologous nerve grafts or collagen.
Dental stem cells can contribute to peripheral nerve regeneration by secreting neurogenic and angiotrophic factors, and by regulating the apoptosis of proximal Schwann cells. "We predict that in the near future dental pulp stem cell transplantation may become a possible candidate for taking the place of autologous nerve grafts in peripheral nerve repair and regeneration," said Dr. Misako Nakashima, DDS, PhD, Department of Dental Regenerative Medicine, Center of Advanced Medicine for Dental and Oral Diseases, National Center for Geriatrics and Gerontology Research Institute in Obu, Japan. According to Dr. John R. Sladek, Jr., of the University of Colorado School of Medicine "DPSCs are derived from the neural crest, making them attractive candidates for neural therapy and repair," The study also suggests the potential, given DPSCs ability to simulate the regeneration of myelinated axons, for their use in future regenerative oriented treatments for MS.
Further in vivo studies will continue to explore the practical applications of dental stem cells in peripheral nerve regeneration. This innovative research illustrates the potential role of stem cell therapies in treating neural injury and neurodegenerative diseases. Banking dental stem cells can provide families with resources to counter future illness. To learn more about banking stem cells, please visit StemSave or call 877-783-6728 (877-StemSave) today.
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