Researchers at the University of Pennsylvania are homing in on how the regenerative properties of dental stem cells can be used to heal wounds and injuries in patients suffering from a variety of afflictions. The catalyst for the research is the numerous studies demonstrating that oral gingival wounds heal faster than cutaneous wounds and exhibit minimal scar formation. To expand the potential applications of these fast healing stem cells, Professor Songtao Shi at Penn Dental Medicine is collaborating with researchers from Peking University, University of Southern California, the Children’s Hospital of Philadelphia and the National Institute of Dental and Craniofacial Research. The researchers homed in on particular proteins secreted by gingival stem cells (a type of dental stem cells) that appeared to rapidly accelerate wound healing in gums compared to wounds on the skin. The researchers looked to utilize these stem cells, and their protein secretions, to test whether they would accelerate healing elsewhere in the body.
The study demonstrated that the (gingival) mesenchymal stem cells release signaling molecules that help regulate the immune response, mitigate inflammation and accelerate repair. The cells produced a protein called IL- 1RA, which is an anti-inflammatory factor that blocks cytokines that activate immune inflammation and cause apoptosis (or cell death) due to the temperature increase at the site of inflammation. The IL-RA1 protein appears to accelerate healing and leaves tissues with minimal scarring. Researchers are exploring the application of these unique stem cells to other wound healing treatments to help patients that suffering from non-healing or chronic wounds from diabetes and other conditions that hinder circulation.
This innovative research demonstrates the integral role stem cells are playing in cutting edge medical care options. By banking their own valuable stem cells, families can ensure that they will have access to these emerging therapies soon. To learn more about banking stem cells, please visit StemSave or call 877-783- 6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
To view the full article, click here.