Researchers at the Bristol School of Cellular and Molecular Medicine are using anchor proteins to guide and keep stem cells in an affected area of the heart to maximize the efficiency of regenerative treatments. The researchers analyzed a protein called adhesin, which is known to locate and attach itself to heart tissue, and they used this property to help attract stem cells to the heart to repair damaged muscle that results from a heart attack or heart disease. The researchers used the adhesin model and created a protein that was on the surface of stem cells and helped guide them directly to heart tissue.
"Our findings demonstrate that the cardiac homing properties of infectious bacteria can be transferred to human stem cells. Significantly, we show in a mouse model that the designer adhesin protein spontaneously inserts into the plasma membrane of the stem cells with no cytotoxity, and then directs the modified cells to the heart after transplant,’ comments lead author of the study Dr. Adam Perriman.
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The Future of Regenerative Medicine is Now™
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