When stem cells are taken out of the body and placed in cultures, the microenvironment that permits the generation of an extracellular matrix is lost, impacting their functionality. To address this shortcoming, a team of researchers from A*STAR Institute of Medical Biology - led by Michael Raghunath and Cedric Badowski, in conjunction with scientists at the National University of Singapore utilized a technique termed 'macromolecular crowding’ [that mimics the microenvironment of the cells] to encourage stem cell differentiation and regeneration.
The team was able to enhance matrix signaling and stimulate reaction mechanisms enabling the differentiation of MSCs into an abundance of fully functioning brown adipocytes [fat cells]. Since brown fat cells are scarce in adults, researchers are exploring safe and effective methods of generating large quantities of brown adipocytes from stem cells to apply their therapeutic potential to metabolic disorders. "Once the potential for this technology is fully explored, we could transform the treatment of metabolic disorders and provide considerable benefits for society," says Badowski.
As regenerative engineering progresses, we believe the best stem cells to use in emerging treatments will be the patient’s own [autologous stem cells] as this negates the need to find a suitable donor and eliminates the chances of rejection of the transplanted tissue. To learn more about banking your own valuable stem cells to insure your family’s future health, visit StemSave or call 877-783-6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
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