Researchers from Harvard University have developed a new growth medium which facilitates the transfer of intact stem cell sheets. Stem cell transplantation is most effective as a coherent surface, rather than a matrix of freely floating cells. Previous attempts to release intact cell sheets have relied on thermal denaturation, which affect transplant efficiency. Slippery Liquid-Infused Porous Surfaces (SLIPS) circumvent this problem by reversibly inducing slipperiness in a cell culture.
Researchers engineered the polymer from the Nepenthes pitcher plant, which in times of rain, reversibly activates slippery surfaces on its leaves to trap insects. This property was mimicked by biocompatible polymeric material polydimethylsiloxane (PDMS), which releases a thin oil layer. The polymer was then coated with human fibronectin, which mesenchymal stem cells adhere to and proliferate. Future research is devoted to the transfer of more complex cell sheets such as muscle tissue or cartilage.
As regenerative engineering progresses, we believe the best stem cells to use in emerging treatments will be the patient’s own [autologous stem cells] as this negates the need to find a suitable donor and eliminates the chances of rejection of the transplanted tissue. To learn more about banking your own valuable stem cells to insure your family’s future health, visit StemSave or call 877-783-6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
To view the full article, click here.