Researchers at the Cincinnati Children’s Hospital are one step closer to reducing organ donor shortages by creating self-organizing human liver tissues. Utilizing innovative genetic sequencing observed in a 3D microenvironment, researchers identified the transcription factors responsible for the signal that causes stem cells to differentiate into liver tissue. This sequence of genes enabled them to program lab-grown liver cells that both genetically, and functionally, closely resemble actual developing liver cells.
This study’s innovation comes from identifying the role of the signaling protein VEGF and its receptors, the activity of which is known to be essential in blood vessel formation of a growing liver. Dr. Takanori Takebe, lead researcher at Cincinnati Children’s states, "The ability to bioengineer transplantable livers and liver tissues would be a great benefit to people suffering from liver diseases who need innovative treatments to save their lives." Clinical trials are expected to be underway soon.
Such advancements in bioengineering should accelerate applications to treat a wider variety of liver disease. By banking their own valuable stem cells, families can ensure that they will have access to these emerging therapies in the near future. To learn more about banking stem cells, please visit StemSave.com or call 877-783- 6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
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