Dr. Christian Jorgensen, head of the clinical unit for osteoarticular diseases, and his team from Lapeyronie University Hospital in Montpellier, France have a treatment for arthritis using the patient’s own [autologous] stem cells. Following the recovery of the stem cells, they were injected directly into the knee joint affected by arthritis. The experiment consisted of three groups receiving different dosages of the stem cells. Interestingly, each group experienced significant improvements in pain and mobility of the joint.
We all take articular cartilage for granted. It takes up a seemingly insignificant amount of space, and somehow absorbs the full pressure our body weight. Arthritis and articular injuries can cause chronic and crippling pain. One group of researchers is developing 3D printed cartilage by bioprinting with an ‘ink’ containing human cells. This technology may one day lead to printed implants, noses, ears, and knees.
Doctors from the Melbourne Stem Cell Center are using stem cells to regrow damaged knee cartilage. Over 70 patients have had their own isolated and expanded mesenchymal stem cells (MSCs) injected into their own knee joints. In initial results, half of those treated at Melbourne Stem Cell Center saw a three-quarters reduction in pain and vastly improved knee function.
Osteoarthritis is the most common chronic condition of the joints, occurring most often in the knees, hips, lower back, and neck. There are approximately 54 million patients in the U.S., of which some 760,000 patients undergo surgery costing an average $33,706, according to the U.S. Center of Disease Control and Prevention. One biotechnology company is combating this problem by utilizing autologous [the patient’s own] stem cells.
The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone.
Topics: osteoporosis, limbs, Fingers, Jaw, Bone loss, Joints, Bone, Debilitating Diseases, Arthritis, Stemcells, Knee, hip, autologousstemcells, cartilage, grants, Mandibular bone, young stem cells, stemsaveblog
As reported on the front page of the New York Times Science section, clinical applications of stem cell based therapies are accelerating at a rate that will revolutionize the medical field in a matter of years. In the United States alone, there are currently over 4000 therapies in clinical trials for the treatment of heart disease, blindness, spinal cord injuries, diabetes, H.I.V., and other diseases, injuries, and traumas.
Topics: Muscular Dystrophy, ALS, Parkinson's, Phase III, multiple sclerosis, Heart, Joints, Alzheimer's, burn injuries, Diabetes, Acute Myocardial Infarction, Brain, Heart Failure, clinical trials, Bone, Debilitating Diseases, Phase II, Arthritis, Stemcells, Teeth, autologousstemcells, cartilage, Amyotrophic lateral sclerosis, Brain Tumors, Blindness, stemsaveblog
In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis. The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue.
Topics: osteoporosis, Fingers, Phase III, Bone loss, Joints, knee replacement, clinical trials, Bone, Debilitating Diseases, Arthritis, Stemcells, Feet, Rheumatoid Arthritis, Hip replacement, Knee, hip, autologousstemcells, cartilage, Cartilage degradation, stemsaveblog
In a recent Phase 1 Clinical Trial, a team of researchers at the National University of Ireland, Galway, were successful in developing a treatment for osteoarthritis that utilizes autologous [the patient’s own] stem cells. According to Professor Frank Barry, scientific director of the Regenerative Medicine Institute at NUI Galway, "Using the patient's own stem cells we have been able to treat their diseased joints and relieve their suffering and burden of pain.”
Arthritis affects 44 million individuals in the US resulting in the need for approximately 700,000 knee-replacement and 100,000 hip replacement surgeries every year. Researchers at Stanford University have developed a technique to track the effectiveness of mesenchymal stem cells [the type of stem cells found in teeth] in repairing arthritic joints. Mesenchymal stem cells are capable of differentiating into bone and cartilage, as well as muscle, fat and tendon. The researchers expect to adapt the study for clinical trials in humans this fall.
A recent study reported by Science News found that a small molecule called kartogenin aids mesenchymal stem cells in differentiating into cells that make up cartilage. The study found that damaged cartilage in the knee can now be regenerated, not only restoring cartilage in the joint but also reducing or eliminating the associated pain of osetoarthritis.