Doctors and Scientist at the Southampton General Hospital have successfully completed a hip transplant by using a titanium socket and a bone scaffold loaded with skeletal stem cells. The team, led by orthopedic surgeon Douglas Dunlap, 3D printed the titanium implant, and then added the bone graft filled with stem cells to the pelvis to encourage bone regrowth behind and around the metal replacement.
In a recent Phase 1 Clinical Trial, a team of researchers at the National University of Ireland, Galway, were successful in developing a treatment for osteoarthritis that utilizes autologous [the patient’s own] stem cells. According to Professor Frank Barry, scientific director of the Regenerative Medicine Institute at NUI Galway, "Using the patient's own stem cells we have been able to treat their diseased joints and relieve their suffering and burden of pain.”
A team of medical researchers at Saint Luc University Clinic have developed a method of repairing bones utilizing autologous [the patient’s own] stem cells. The process involves harvesting the stem cells from the patient, differentiating the stem cells in-vitro to grow bone, pairing the cells with a scaffolding matrix and then molding the material to repair damaged or diseased bone within the patient.
A team of scientists from Karlsruhe Institute of Technology, Max Planck Institute for Intelligent Systems, and the University of Tubingen have recently developed a prototype of artificial bone marrow. The bone marrow retains all of its basic properties, including the ability to regenerate hematopoietic stem cells, which can be used to treat patients with leukemia.
Researchers from Karolinska Institutet’s Department of Clinical Sciences have developed an application for mesenchymal stem cells [the same type found in Dental Stem Cells] to provide treatment for children born with osteogenesis imperfecta. The researchers utilized the unique properties of MSCs to facilitate and improve bone tissue formation through in utero transplantations.
Orthopedic Surgeons are utilizing autologous [the patient’s own] stem cells to treat injuries and degenerative diseases in the joints and bones of athletes. The treatments involve the recovery of the patient’s own mesenchymal stem cells - which are particularly plastic and can differentiate into a variety of tissue types and implanting them back into the damaged bone or joint to reduce inflammation and regenerate damaged tissue without the need for invasive surgery.
Researchers at Melbourne’s St. Vincent Hospital and the University of Wollongong are engineering a device known as the “Biopen” to deliver stem cells to damaged or diseased bones. This novel method of stem cell therapy administers a mixture of jelly and stem cells into the damaged sections of the bone. The jelly is then UV-dried into a scaffolding to facilitate stem cell growth and bone regeneration.
A study team from Kobe University Graduate School of Medicine in Japan has developed a treatment for hard to heal bone fractures. The treatment makes use of autologous [the patient’s own] stem cells to promote proper healing in fractures that fail to heal on their own.
In a follow-up study, stem cells from teeth were found to provide a viable and stable repair mechanism for mandibular bone defects. Three years after the clinical trial was initiated, the bone is still functioning properly.
Researchers all around the world are working towards utilizing stem cells to grow replacement organs. While once thought to be a futuristic concept, it is now very real. Doctors and researchers have successfully transplanted lab grown bladders, blood vessels, tear ducts, arteries and windpipes. Now, research teams around the world are growing urethras, bile ducts, larynxes, bones, livers, kidneys, and even hearts.