In a clinical study, researchers at Queen Mary University of London will utilize autologous stem cells to reboot the immune system of Crohn’s disease patients, with the aim of greatly alleviating the inflammation of the bowel thus significantly improving the patients’ quality of life. Crohn’s disease is an autoimmune disorder in which portions of the bowel are attacked by the immune system leading to severe inflammation, malnutrition and debilitating abdominal pain. Though there is currently no effective cure, this stem cell treatment has shown promise in treating the erroneous attacks of the immune system on the bowel tissues. The treatment involves a stimulation of the bone marrow to release stem cells, which are then harvested, followed by an irradiation of the body to eliminate the malfunctioning immune system. The recovered healthy immune stem cells are then reinfused into the body to reboot the immune system and eliminate the inflammation of the bowels.
In a newly published phase II clinical trial from the Asan Medical Center in Seoul, Korea, researchers observed full recovery from fistulas [abnormal connections between organs caused by the inflammation] in 75% of patients suffering from Crohn’s disease upon the injection of autologous [the patient’s own] stem cells. MSCs have the ability to regulate the patient’s immune system to reduce inflammation, resulting in the complete closure of the fistulas without recurrence.
Topics: large intestine, bank dental stem cells, Crohn's Disease, autologousstemcells, autoimmune disease, gastrointestinal disease, autoimmune attack, research, StemSave, mesenchymal stem cells, organs, stem cells, Fistulas
Scientists at the Cincinnati Children’s Hospital Medical Centre have induced adult stem cells to differentiate into small clusters of gastric tissue that replicate the functions of the human stomach. The lab-made structures, known as “mini-stomachs”, were created by replicating the chemical pathways of early stage stomach development of stem cells in a petri dish.
Researchers from the Cincinnati Children’s Hospital Medical Centre have successfully grown functional human intestinal tissues by utilizing stem cells. After stimulating the stem cells with a “molecular cocktail” of chemicals and growth factors, the team observed as the cells developed into the mucosal lining and muscle layers, while exhibiting digestive functions such as nutrient uptake and responding to molecular signals.
Topics: Gastrointestinal cancer, ulcerative colitis, Debilitating Diseases, Stemcells, Crohn's Disease, Thanksgiving, autologousstemcells, intestinal tissue, small intestine, Inflammatory Bowel Disease, stemsaveblog
Inflammatory Bowel Disease (IBD) is a group of inflammatory conditions of the colon and small intestine. The major types of IDB are Crohn’s Disease and ulcerative colitis. In the US, approximately 1 million people suffer from diseases that fall under the category of IBD. Treatments for this disease ordinarily include steroids and immune-suppressors. However, researchers at Wake Forest have recently discovered a population of stem cells that may be able to treat IBD without the use of either steroids or immune-suppressors.