Researchers in Japan have made headway in bringing tooth regeneration to clinical trials. This major breakthrough involved utilizing both epithelial and dental stem cells to create tooth buds that were then implanted into the jaw bone. The ‘tooth buds’ grew into fully functional adult teeth in the span of 5 months. In this animal model, the researchers first used a biological scaffold and seeded the epithelial and dental stem cells to create a tooth bud, which acts like a seed for a new tooth to grow. This is similar to the tooth buds that children have below their deciduous teeth (baby teeth). The study showed that the regenerated tooth maintained both biological form and function, including a response to orthodontic force that caused the biological implanted tooth to move in the same way a normal tooth would.
Hypoxic-Ischemic brain injury can be caused by a number of ailments including cardiac arrest (heart attack), respiratory arrest, incomplete suffocation and more. The incidence in the United States of hypoxic-ischemic brain injuries is 1-8 in every 1000 births. Researchers at Nagoya University have used stem cells from human exfoliated deciduous teeth (SHED) to treat neonatal mice with hypoxic-ischemic brain injuries. They have found that this treatment leads to neurological and pathophysiological recovery of these injuries. These finding indicate that SHED may be utilized in the future for a novel neuroprotective therapy for hypoxic-ischemic brain injuries.