Researchers at the American Chemical Society (ACS) have developed a biopolymer that would be implanted into an affected gum line to recruit stem cells and restore the damage caused by periodontal disease. With the Centers for Disease Control predicting that nearly half of all Americans will be affected by periodontal disease during their lifetimes, the new regenerative treatment technique would save healthy teeth, avoid prolonged and costly treatments and provide dentists with a more effective and less invasive treatment option for their patients.
Researchers are utilizing vesicles secreted from dental stem cells to treat Parkinson’s Disease (PD). The study utilized these vesicles secreted by stem cells, as they are small and can easily cross the blood-brain barrier to deliver a treatment to the parts of the brain affected by PD. Parkinson’s is a neuro-degenerative disorder that affects the part of the brain that produces a neurotransmitter called dopamine, with symptoms expressing themselves as tremors and limb rigidity, among others. This study demonstrated, in an animal model, that intranasal administration of dental stem cell vesicles had a therapeutic effect by regulating the expression of proteins and preventing dopaminergic neuron death. The results showed a decrease in PD tremors and showed no adverse neurological effects over the progression of the study.
Researchers at Adelaide University in Australia are conducting research into the application of dental pulp stem cells to treat neurological damage due to stroke. Cell based treatments for the detrimental effects of stroke could improve quality of life by promoting neural regeneration, neuroplasticity, vascularization and immuno-modulation. When an ischemic stroke occurs, a major artery in the brain becomes blocked due to a blood clot, and this deprives part of the brain of nutrients and oxygen. Depending on the length of the block, major parts of the brain can suffer neuronal death causing severe and permanent damage. This damage includes paralysis, vision problems, memory loss and language difficulties. Currently, there are no effective treatments for the effects of stroke, and because dental stem cells are derived from the neural crest during embryonic development, a dental stem cell based treatment shows promise in significantly improving the quality of life for stroke victims.
Researchers in Japan have made headway in bringing tooth regeneration to clinical trials. This major breakthrough involved utilizing both epithelial and dental stem cells to create tooth buds that were then implanted into the jaw bone. The ‘tooth buds’ grew into fully functional adult teeth in the span of 5 months. In this animal model, the researchers first used a biological scaffold and seeded the epithelial and dental stem cells to create a tooth bud, which acts like a seed for a new tooth to grow. This is similar to the tooth buds that children have below their deciduous teeth (baby teeth). The study showed that the regenerated tooth maintained both biological form and function, including a response to orthodontic force that caused the biological implanted tooth to move in the same way a normal tooth would.
Author Kali Sakai, reports on banking stem cells from teeth in Parent Map. The daughter of a dentist, Sakai learned about teeth, however she was unaware of the stem cells inside teeth. As Sakai states, “It blew my mind to think that my child’s baby tooth could hold the key to a life-saving treatment in her adulthood”.
Researchers at the Sri Ramachandra University (SRU) in Chennai have differentiated stem cells from human gum [gingival] tissue into neurons. Following their success, Dr. R. Suresh and research scholars S. Rajasekharan and M. G. Dinesh hope to develop methodologies to utilize the differentiated nerve cells to treat spinal cord injuries.
Dr. Mao’s lecture focused on a variety of insights on the science, technology, and medical impact of stem cells and regenerative medicine including one of the overarching goals of stem cell researchers;reducing the health care expenditure in the US while delivering therapies and treatments that will lead to longer, healthier lives.
A research article recently published by Dr. Arnold Caplan Ph.D, and Dr. Irina Kerkis Ph.D examines the proliferative capabilities and plasticity of stem cells found in both baby teeth (DTSC) and adult wisdom teeth( DPSC).
By examining the origin and development of both types of teeth, the researchers found that both baby and wisdom teeth are highly proliferative and plastic, making them conducive to cryo-preservation and future harvesting. The article notes that stem cells derived from baby teeth have particular proliferative capacity because of the high concentration of stem cells in young teeth.
The eighth annual program on Stem Cell Biology and Regenerative Medicine will convene this summer in Hydra, Greece. The program provides intensive training on fundamental concepts of stem cell biology and provides further insight on stem cell research and regenerative medicine as an integral part of the progressive future of medicine. Leading experts will give an in-depth, week-long programme of lectures, workshops and discussion groups. The summer school is open to postgraduate research students, postdoctoral researchers, senior researchers, clinical training fellows and technicians from universities, research institutes and industry, working in stem cell biology or related fields.
Professor Gordana Vunjak-Novakovic, one of StemSave's Scientific Advisers, has just been elected to the prestigious National Academy of Engineering (NAE), one of the highest professional distinctions awarded to an engineer, for her work with bioreactor systems and modeling approaches for tissue engineering and regenerative medicine. She joins only 2,500 engineers around the world.
Topics: stemsaveblog, wisdom teeth, columbia university, wisdom teeth stem cells, dental stem cells, baby teeth stem cells, Stem Save, professor gordona vunjak-novakovic, life sciences, national academy of engineering, banking stem cells, stem cell harvest