Researchers at Texas A&M University are utilizing stem cell injections into the brain to alleviate the most common and severe case of seizures of Temporal Lobe Epilepsy (TLE) in an animal model. The experimental treatment resulted in 70% of the subjects experiencing a reduction in the number of seizures with researchers expecting the number to climb as the research advances. Current treatment of TLE involves treatment with medication [to which 40% of patients do not respond] or, invasive surgery. To eliminate this type of epilepsy, some patients have their entire hippocampus removed, which can lead to disastrous side effects impacting the patient’s mood and memory.
A team at Texas A&M University’s College of Medicine has been working on a treatment to address the side effects of epileptic seizures utilizing vesicles from stem cells. The most significant side effect of seizures is inflammation in the brain, which anti-seizure drugs do not typically treat. The vesicles, known for their anti-inflammatory properties, are separated and recovered from mesenchymal stem cells [MSCs] and delivered via a nasal spray to promote rapid delivery to the brain. Separating the vesicles from their stem cells allows them to penetrate barriers not permeable by the whole stem cell, thereby increasing their efficacy in limiting damage caused by inflammation.