The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patient’s own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patient’s own bone.
Topics: osteoporosis, limbs, Fingers, Jaw, Bone loss, Joints, Bone, Debilitating Diseases, Arthritis, Stemcells, Knee, hip, autologousstemcells, cartilage, grants, Mandibular bone, young stem cells, stemsaveblog
In a new pilot study at the Royal National Orthopaedic Hospital in London, researchers will utilize stem cells to promote the healing of painful tendon injuries such as tennis elbow. Initial studies suggest that, upon transplantation, the stem cells release growth factors to the point of injury, which induce the growth of new tendon tissue while reducing scar tissue to recover movement and flexibility.
As reported on the front page of the New York Times Science section, clinical applications of stem cell based therapies are accelerating at a rate that will revolutionize the medical field in a matter of years. In the United States alone, there are currently over 4000 therapies in clinical trials for the treatment of heart disease, blindness, spinal cord injuries, diabetes, H.I.V., and other diseases, injuries, and traumas.
Topics: Muscular Dystrophy, ALS, Parkinson's, Phase III, multiple sclerosis, Heart, Joints, Alzheimer's, burn injuries, Diabetes, Acute Myocardial Infarction, Brain, Heart Failure, clinical trials, Bone, Debilitating Diseases, Phase II, Arthritis, Stemcells, Teeth, autologousstemcells, cartilage, Amyotrophic lateral sclerosis, Brain Tumors, Blindness, stemsaveblog
In recent clinical trials, researchers at the National University of Ireland Galway have successfully utilized adult stem cells to treat patients with osteoarthritis. The treatment involves recovering the patients’ own [autologous] stem cells and then injecting the stem cells into cartilage to stimulate the regeneration of lost tissue.
Topics: osteoporosis, Fingers, Phase III, Bone loss, Joints, knee replacement, clinical trials, Bone, Debilitating Diseases, Arthritis, Stemcells, Feet, Rheumatoid Arthritis, Hip replacement, Knee, hip, autologousstemcells, cartilage, Cartilage degradation, stemsaveblog
Doctors and Scientist at the Southampton General Hospital have successfully completed a hip transplant by using a titanium socket and a bone scaffold loaded with skeletal stem cells. The team, led by orthopedic surgeon Douglas Dunlap, 3D printed the titanium implant, and then added the bone graft filled with stem cells to the pelvis to encourage bone regrowth behind and around the metal replacement.
In a recent Phase 1 Clinical Trial, a team of researchers at the National University of Ireland, Galway, were successful in developing a treatment for osteoarthritis that utilizes autologous [the patient’s own] stem cells. According to Professor Frank Barry, scientific director of the Regenerative Medicine Institute at NUI Galway, "Using the patient's own stem cells we have been able to treat their diseased joints and relieve their suffering and burden of pain.”
A team of medical researchers at Saint Luc University Clinic have developed a method of repairing bones utilizing autologous [the patient’s own] stem cells. The process involves harvesting the stem cells from the patient, differentiating the stem cells in-vitro to grow bone, pairing the cells with a scaffolding matrix and then molding the material to repair damaged or diseased bone within the patient.
In a recently aired video on Reuters News, Dr. Jeremy Mao, of Columbia University, and Chief Scientific Adviser to StemSave, discusses his use of scaffolding and stem cells to rebuild functioning joints in rabbits. An application to begin clinical [human] trials has been filed with the FDA. Dr. Mao believes that stem cell regeneration will be the answer for hundreds of thousands of patients who, each year, undergo joint replacement. He anticipates a time, in the very near future, when patients will grow their own new knee or hip joints utilizing their own stem cells and the technique he has developed.
Cartilage injuries can range from small lesions, such as those of athletes, to chronic injuries, such as cartilage degradation. Cartilage injuries, which are difficult to repair and have limited options for surgery, and usually results in a drastic affect on quality of life of afflicted individuals. In addition, the health, number and vitality of cartilage cells diminish with age.