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Stem Cells Undo Opioid Tolerance

Posted by on Aug 21, 2015 1:41:00 PM

Researchers at the Cleveland Clinic reported that treating animal subjects with mesenchymal stem cells prevented opioid tolerance despite repeated exposure. Stem cells, when provided after opioid tolerance was established, essentially reversed both tolerance and hypersensitivity to pain associated with opioid tolerance. Although opioids like morphine are essential to the treatment of pain, tolerance requires the use of increasingly higher doses which carry potentially significant morbidity.

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Topics: stemsaveblog, inflammation, mesenchymal stem cells, morphine, pain management, opioid, chronic pain


AAOMS - American Association of Oral and Maxillofacial Surgeons


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