Sepsis is a systemic inflammatory response to severe infection, impairing metabolic function across all organ systems--affecting some 28 million people and claiming 8 million victims worldwide each year. Septic shock can lead to permanent neurological and muscular damage. Researchers at the Ottawa Hospital hope to change these statistics with an innovative therapy using injections of mesenchymal stem cells.
The American Academy of Pain Medicine has recognized mesenchymal stem cell [MSC] treatments as a viable method to block opioid-induced tolerance. The Academy cites a study done by the Cleveland Clinic in which the development of opioid tolerance was effectively prevented by either intravenous or intrathecal MSCs. Furthermore, established opioid tolerance was reversed when the timing of the transplants followed repeated morphine injections.