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Magnetizing Stem Cells to Treat Bone Cancer

Posted by on Jul 16, 2019 3:01:00 PM

Researchers at University of California Irvine (UCI) have engineered mesenchymal stem cells (MSCs) to locate metastases of cancer in bone and deliver targeted therapeutic factors that destroy the cancer but not the surrounding bone. The issue with conventional cancer treatments like chemotherapy is that although the treatment often successfully kill the cancer cells, they also severely damage the surrounding tissue, leading to a plethora of side effects. For this study, the researchers used MSCs that were genetically engineered to express surface proteins that are known to interact with cancer cells. Additionally, the stem cells expressed factors that prevent bone resorption, which would otherwise lead to bone loss following the cancer treatment.

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Topics: stem cell cancer treatment

3D Bio-Printing Esophagus Replacements for Cancer Patients

Posted by on Jun 24, 2019 2:05:00 PM

Researchers at Seoul National University Hospital are using stem cells to reconstruct segments of the esophagus due to birth defects or damage following treatments for cancer. The current standard of care has several drawbacks, since it involves taking a portion of a patient’s small intestine to reconstruct the esophagus when all, or part, of it is removed. In an animal model researchers 3D printed a two-layered scaffold using nanofibers in the shape of an actual esophagus, then seeded the scaffold with mesenchymal stem cells (MSCs). The technique enables researchers to cater the shape to the exact specifications for the form and function of the esophagus, including the placement of the thyroid gland flap.

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Topics: stem cell cancer treatment


AAOMS - American Association of Oral and Maxillofacial Surgeons


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