Dr. Gordana Vunjak-Novakovic [a member of StemSave’s Scientific Advisory Council] and her colleagues at Columbia University have created living jaw bone from stem cells paving the way for regenerative therapies in facial reconstruction. Using a CT scan to create a 3D image of each jaw, the team created a scaffold that, when infused with stem cells, formed new bone identical to the original.
StemSave is once again sponsoring the International Conference on Dental and Craniofacial Stem Cells [ICDCSC]. This is the 3rd conference since the inaugural conference of 2012 and will be held on October 26-28 in Paris, France. The conference will be co-chaired by Dr. Jeremy Mao of Columbia University [StemSave’s Chief Scientific Advisor] and Dr. Michael Goldberg of University Paris Descartes. They will be joined by 30 internationally renowned speakers in a collegial and conducive atmosphere to catalyze the biology of stem cell research and translational advances towards therapeutics.
Dr. John Szivek, a researcher from the University of Arizona, is growing cartilage from stem cells. The process would utilize the patient’s own stem cells. The grown cartilage would be used to repair arthritic related damage, both small and large, and may one day eliminate the need to put plastics and/or metals in patient’s joints.
Researchers at Mass General Hospital have built a rat forelimb with functional muscular and
vascular tissue using progenitor stem cells. The approach may be useful in developing
replacement limbs for transplantation in primates. The team, led by Dr. Harald Ott, injected
muscle progenitor cells into a cell-free matrix that preserved nerves and primary vasculature;
two weeks later, analysis confirmed the presence of blood vessel walls within vascular cells and
aligned muscle cells within the muscle matrix.
New research from the Eye Program at the Cedars-Sinai Board of Governors Regenerative Medicine Institute demonstrates how a single injection of adult human stem cells can preserve eyesight in an animal suffering from Age-Related Macular Degeneration [AMD] for the equivalent of 16 years. Upon injection, the stem cells began to recruit other healthy cells towards the retina to form a protective layer, which prevented further macular degeneration.
Recently published research from the Yale University Cancer Center has evaluated the effect of a stem cell’s surrounding area on whether or not the cell will grow or die. The scientists, led by Kailin R. Mesa, observed stem cells on a hair follicle using live microscopic imaging to determine that the environment in which the stem cell is located plays a critical role in the fate of that cell. Mesa’s team also observed that stem cells contain a feeding mechanism to rid the skin area of dead cells.
A recent clinical trial conducted at Great Ormond Street Hospital in London, England, has successfully treated seven patients suffering from the genetic disorder Wiskott-Aldrich Syndrome by utilizing autologous [the patient’s own] stem cells. The therapy was an example of translational genomics, in which doctors extract autologous stem cells, correct the faulty gene that causes Wiskott-Aldrich Syndrome, and then implant the stem cells back into the patients to produce new, healthy cells.
In a newly published article by the Wall Street Journal, a team of Columbia and Cornell researchers led by Dr. Jeremy Mao [a member of StemSave’s Scientific Advisory Council] has developed a potential method to treat patients with torn menisci. The method involves 3D-printing a biodegradable scaffold of the meniscus, infusing it with growth factors, and implanting it into the knee. Once in the patient’s body, the growth factors should attract autologous [the patient’s own] stem cells to generate a new, natural meniscus.
Recently published research out of South Korea has presented a new method of differentiating mesenchymal stem cells [MSCs] into liver cells for autologous use in regenerative medicine. Geneticists found that the overexpression of two genes within MSCs, oct4 and sox2, resulted in the stem cells converting into fully functional hepatocytes, or liver cells, capable of producing urea and storing glycogen.
Topics: hepatocytes, liver cells, regenerate organs, Stemcells, stem cell differentiation, Liver disease, research, StemSave, mesenchymal stem cells, autologous stem cells, stem cells, biology, adult stem cells