Researchers at the University of Pennsylvania school of Dental Medicine have elucidated the mechanism behind mesenchymal stem cell transplants in lupus patients, who typically suffer greater risk of osteoporosis. Prior work with stem cells has led to improvements in their condition, but until the current study, the process by which gains were made have been poorly understood.
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that compromises health, mobility and quality of life. Current treatments address the symptoms of the disorder but fail to address its underlying causes. In a study utilizing mesenchymal stem cells (MSCs) in an animal model, transplants of MSCs reduced inflammation and attenuated nephritis (kidney infection).