Complex chemical polymers are currently being developed by scientists at Stanford University to protect and support the proliferation of stem cells during spinal cord transplantation procedures. The gels are designed to provide padding for the cells during injection, while also varying in viscosity and the biochemical signals contained within to offer stem cells an optimal environment for differentiation.
A recent clinical trial conducted by the University of Genoa has determined that mesenchymal stem cell therapy to treat multiple sclerosis is indeed safe to perform on humans. 27 MS patients completed the study, which comprised an injection of the patient’s own [autologous] mesenchymal stem cells [MSCs] to reduce excessive inflammation caused by the patients’ own immune systems. None of the patients suffered any side effects from the injection.
Topics: limbs, Phase III, traumatic brain injuries, neural stem cells, multiple sclerosis, stemsaveblog, clinical trials, Debilitating Diseases, Phase II, Stemcells, autologousstemcells, Neurodegenerative disease
As reported in a recent article in the New York Times, bioengineers from Tufts University have created a 3-D model of the brain that, utilizing stem cell-derived neurons, the model can mimic the brain’s response to traumatic injury. Principle Investigator Dr. David Kaplan tested the model by dropping weights on it, resulting in a complete neuronal response, including the transmission of electrical impulses and chemical signals through the neurons.
As reported by the Wall Street Journal, adult stem cell therapies are advancing rapidly; with researchers utilizing stem cells to treat an expanding range of disease, trauma and injury. The article highlights the increasing use of cord blood to treat a variety of ailments such as; Cerebral Palsy, Traumatic Brain Injury and immune deficiencies such as diabetes.
A study from the University of Texas Health Science Center has discovered a novel function of mesenchymal stem cells in preventing long-term brain damage and inflammation in patients following traumatic brain surgery. MSCs injected into TBI-mice actually travelled to the spleen to regulate the body’s inflammatory response to the trauma and preserve brain function.
Researchers at the University of Texas Health Science Center have developed a novel use of stem cells to prevent neurological inflammation in patients following traumatic brain injury; potentially limiting damage caused by TBI and preserving brain function for victims. The treatment stem cells injected into TBI-mice regulated the immune response in the brain, limiting inflammation and long term damage.
Researchers at the University of South Florida have successfully used adult stem cells to repair traumatic brain damage in neurologically impaired mice. Prior to the study, hypotheses on how stem cells may provide treatment for neurological disorders were limited. However, the results of this experiment provide a new theory: stem cells replace dying cells while attracting other stem cells from uninjured regions of the brain to the damaged portions for continued neural cell replenishment. In the words of Principal Investigator Dr. Cesar Borlongan, "The transplanted stem cells serve as migratory cues for the brain's own neurogenic cells."
Dr. Peter Donovan, Dr. Hans Keirstead, Dr. Aileen Anderson, Dr. Brian Cummings, Dr. Frank LaFerla, Dr. Leslie M. Thompson, and Dr. Matthew Blurton-Jones of UC Irvine discuss the importance of stem cells and the current research taking place within their labs.