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Treating Diabetes and Obesity with Stem Cells

Posted by anna@stemsave.com on Jun 10, 2019 11:55:00 AM

Researchers, led by Dr. Bing Wang, Professor in the Department of General Surgery at Shanghai Ninth People's Hospital and Shanghai Jiao Tong University School of Medicine in Shanghai, China, are utilizing mesenchymal stem cells (MSCs) to treat obesity and type II diabetes, two of the most significant healthcare concerns for adults worldwide. This study explored the use of MSCs (the same type of stem cells found in teeth) to treat the inflammation due to obesity that often causes or exacerbates the insulin resistance in type II diabetes. In an animal model, the stem cells were used to to restore metabolic balance and mitigate insulin resistance that arises when high blood glucose levels persist for extended periods of time. The stem cells, known for their anti-inflammatory properties, also expressed a growth factor called neuregulin 4, which is known to effectively combat the effects of obesity.

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Topics: obesity, type 2 diabetes, stem cell diabetes treatment

Stem Cells Accelerate Diabetic Wound Healing

Posted by davids@stemsave.com on Oct 22, 2018 3:04:00 PM

Mesenchymal stem cells (MSCs) have been found to be effective in accelerating healing time for diabetics. In patients with diabetes, high blood sugar levels negatively impact circulation and impair the immune system’s ability to fight off infections at the site of wounds. In an animal study, adipose derived MSCs, proved to be effective at decreasing inflammation and increasing circulation around wounds. Previous studies have utilized MSCs recovered from bone marrow. This study demonstrates the potential of MSCs, which can be derived from multiple sources, including teeth, to treat the millions of diabetics around the world who suffer from this debilitating affliction.

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Topics: Type-1 Diabetes, diabetic wounds, type 2 diabetes, treating diabetes, mesenchymal stem cells, stem cell diabetes treatment

Type 2 Diabetes Mellitus - Stem Cell Clinical Trials

Posted by devin@stemsave.com on Dec 19, 2017 4:45:00 PM

In several clinical and animal studies, researchers are utilizing mesenchymal stem cells (MSCs) to treat Type II Diabetes Mellitus (T2DM). Type 2 Diabetes affects approximately 415 million people worldwide, with diabetes mellitus (DM) further exacerbating diabetes’ adverse health effects. Symptoms of DM are caused by both a lack of insulin, as-well-as an intolerance to the scarce amount of insulin that is produced by the pancreatic islet cells. DM is typically a precursor to ischemic heart disease, stroke, blindness and chronic kidney disease with no effective treatments currently available to prevent these complications. With previous treatments using donated organs and insulin producing cells proving unsuccessful, MSCs are emerging as an extremely effective tool to restore normal function to the pancreatic islet cells and alleviate the other symptoms of DM. MSCs (the same type of stem cells that are found in teeth) not only normalize natural insulin levels, but also help ameliorate insulin resistance in the body’s tissues by creating a favorable microenvironment.

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Topics: pancreatic beta cells, type 2 diabetes, mesenchymal stem cells, diabetes mellitus, stem cell diabetes treatment, pancreatic islet cell regeneration

Fighting Type II Diabetes with Stem Cells

Posted by barb@stemsave.com on Aug 18, 2017 4:30:00 PM

Researchers at the University of Chicago have developed a skin graft utilizing engineered stem cells that can trigger the release of insulin and successfully regulate blood sugar levels, as well as prevent weight gain when consuming a high-fat diet. This revolutionary treatment could eliminate the pain and discomfort from current methods of monitoring and regulating blood sugar through injections. The stem cells in the graft were engineered, with the use of CRISPR, to release a hormone that mimics glucagon (called GLP-1) and trigger the pancreas to release insulin. GLP-1 is also shown to combat obesity due to its appetite suppressing properties. The engineered stem cells formed into a layer of skin tissue and were applied to the subjects. In animal models, 80% of the diabetic mice receiving the engineered skin graft exhibited the release of insulin following food consumption resulting in lower blood glucose levels and reduced body weight.

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Topics: insulin secreting cells, type 2 diabetes, regenerative medicine, stem cell skin graft

AAOMS

AAOMS - American Association of Oral and Maxillofacial Surgeons

 

As the industry leader, StemSave is the only stem cell banking service to be designated as an ASI approved program.

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