Researchers at Keio University in Tokyo have developed a method to generate platelets negating the need to obtain them from donated blood. Typically, platelets come from blood donations and have an extremely short shelf-life of 5 days. Platelets are vital to a great number and variety of medical procedures as they are responsible for clotting and can prevent patients from bleeding out from serious injuries or during surgeries. Additionally, platelets are difficult to match from donor to patient and donated platelets run the risk of rejection by the recipient. Creating a patient’s own platelets from their own stem cells would negate the need for a donor and virtually eliminate any possibility of rejection. Generating patient specific platelets would also alleviate the shortages that are typical of the current platelet recovery environment.
When tested in the lab, the stem cell derived platelets demonstrated higher levels of platelet binding surface proteins and were able to induce platelet aggregation to the areas that would require clotting. Additionally, in vivo testing following irradiation showed that the stem cell derived platelets closely resembled the behavior of actual platelets. Lead researcher Yumika Matsubara, PhD, comments “Now that we have established an efficient manufacturing process to yield a large number of platelets, we next plan to perform preclinical studies using animal models to demonstrate efficacy and safety, followed by clinical trials in human patients.”
This advancement in bio engineering will accelerate the trend of personalized medicine and broaden stem cell applications. By banking their own valuable stem cells, families can ensure that they will have access to these emerging therapies in the near future. To learn more about banking stem cells, please visit StemSave or call 877-783- 6728 (877-StemSave) today.
The Future of Regenerative Medicine is Now™
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